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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
重叠综合征对慢性阻塞性肺疾病患者胱抑素C及β2微球蛋白水平临床分析
Clinical analysis of plasma cystatin-C and 2-microglobulin levels in patients with overlap syndrome(OS)and chronic obstructive pulmonary disease(COPD)
投稿时间:2018-08-30  修订日期:2018-09-24
DOI:
中文关键词:  重叠综合征;慢性阻塞性肺疾病; 胱抑素C;β2微球蛋白
英文关键词:overlap syndrome(OS); chronic obstructive pulmonary disease(COPD);cystatin-C(Cys-C);2-microglobulin(β2-MG)
基金项目:
作者单位E-mail
邹春芳 南京市第一医院呼吸与危重症医学科 13951972607@163.com 
谷伟 南京市第一医院呼吸与危重症医学科 guw2001@126.com 
王丽 南京市第一医院呼吸与危重症医学科 13815856115@139.com 
陈玉宝 南京市第一医院呼吸与危重症医学科 interloper9@163.com 
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中文摘要:
      【摘要】 目的:对比重叠综合征(OS)和慢性阻塞性肺疾病(COPD)患者血清胱抑素C(Cys-C)和?2微球蛋白(?2-MG)水平,并探讨其对早期肾损伤的诊断价值。方法:筛选出12例OS患者做为观察组(A组)及38例COPD患者做为对照组(B组),并将对照组按照缺氧程度分为B1、B2及B3组。分别测定肺功能及血清尿素氮、肌酐、Cys-C及?2-MG水平,观察各指标差异及分析相关性。结果:A组和B组比较:慢性阻塞性肺病评估测试(CAT)、PCO2、Cys-C和?2-MG高于B组,PO2低于B组,P<0.05;相关性分析:Cys-C及b2-MG和PO2呈负相关,和CAT呈正相关; 亚组分析:A组的PO2低于对照各亚组,A组分别和B1组及B2组比较有统计学意义;A组的PCO2高于对照各亚组,P<0.05;A组的Cys-C及?2-MG水平皆高于各亚组,分别和B1及B2组比较P<0.05,但和B3组比较P>0.05;各对照亚组之间Cys-C水平比较P<0.05,三组之间的?2-MG水平:B1和B2、B1和B3比较有统计学意义,而B2和B3 比较P>0.05,其它指标无显著性差异。结论:和COPD患者相比,OS患者缺氧明显及二氧化碳潴留严重,Cys-C及?2-MG更为升高,并和缺氧密切相关;可以检测Cys-C及?2-MG早期发现肾损伤。 【关键词】 重叠综合征;慢性阻塞性肺疾病; 胱抑素C;?2微球蛋白
英文摘要:
      【Abstract】 Objective To compare the serum levels of cystatin C(Cys-C) and ?2-microglobulin( β2-MG) in patients with overlap syndrome(OS) and chronic obstructive pulmonary disease(COPD),and to explore their diagnostic value in early renal injury. Method A total of 12 patients with OS were selected as observation group (group A) and 38 patients with COPD as control group (group B). The control group was divided into B1, B2 and B3 groups according to the degree of hypoxia.Pulmonary function and the levels of blood urea nitrogen(BUN), serum creatinine (Scr),Cys-C and β2-MG were measured, and the differences of each index were observed and the correlation was analyzed. Result The levels of COPD?assessment?test(CAT), PCO2, Cys-C and β2-MG in group A were higher than those in group B and PO2 was lower than that in group B,P<0.05. Correlation analysis: Cys-C and β2-MG were negatively correlated with PO2 and positively correlated with CAT. Subgroup analysis:The PO2 of group A was lower than that of control subgroup. Group A was statistically significant compared with group B1 and group B2 respectively. The PCO2 of group A was higher than that of control subgroup.The differences was all statistically significant.The levels of Cys-C and β2-MG in group A were higher than those in control subgroup. Group A was statistically significant compared with group B1 and group B2 respectively.But there was no statistical significance compared with group B3.There was a significant difference between B1, B2 and B3 groups in Cys-C.The level of β2-MG of the three groups :the differences was statistically significant between B1and B2, B1and B3, there was no difference between B2 and B3.There was no significant difference in other indexes. Conclusion Compared with COPD patients, OS patients had significantly anoxia and severe carbon dioxide retention,Cys-C and β2-MG were more elevated and closely related to hypoxia. Cys-C and β2-MG can be detected in early detection of renal injury. [keywords] overlap syndrome(OS); chronic obstructive pulmonary disease(COPD);cystatin-C(Cys-C);?2-microglobulin(β2-MG)
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