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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
阿尔茨海默病患者精神行为症状与外周血单核细胞百分比的相关性研究
A study on percentage of monocytes in peripheral blood of patients with Alzheimer’s disease with neuropsychiatric symptoms
投稿时间:2018-11-15  修订日期:2019-01-02
DOI:
中文关键词:  阿尔茨海默病;精神行为症状;单核细胞
英文关键词:Alzheimer’s disease;behavioral and neuropsychiatric symptoms of dementia;monocytes
基金项目:
作者单位E-mail
高文超 北京老年医院精神心理二科 15201304227@163.com 
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中文摘要:
      目的 研究伴有精神行为症状的阿尔茨海默病(AD)患者外周血单核细胞百分比与精神行为症状的相关性。方法 以2018年1-10月因精神行为症状入我科治疗的37例AD患者为病例组,采集静脉血,测定单核细胞百分比及单核细胞数,同时行神经精神问卷(NPI)评分,选择同期入院无精神行为症状的37名AD患者作为对照组,进行相同检测,治疗1个月后对两组患者进行再次测评相同指标,对结果进行评价。结果 入院时病例组单核细胞百分比明显高于对照组[(8.56±0.92)vs(5.36±0.32);P<0.05];治疗1个月后,病例组NPI评分下降[(26.49±6.17)vs(45.89±7.78);P<0.05],同时单核细胞百分比较入院时下降[(5.54±0.41)vs(8.56±0.92);P<0.05]但高于对照组治疗后[(5.54±0.41)vs(5.33±0.33);P<0.05],而对照组治疗前后单核细胞百分比无明显变化(P>0.05);病例组入院及治疗后单核细胞百分比与NPI评分成正相关(r=0.736,P<0.05;r=0.579,P<0.05)。结论 AD患者的精神行为症状与外周血单核细胞百分比存在正相关关系。
英文摘要:
      Objective To investigate the percentage of monocytes in peripheral blood of patients with Alzheimer’s disease with neuropsychiatric symptoms. Methods A total of 74 patients diagnosed with AD were recruited between January and October 2018. 37 patients with behavioral and psychological symptoms of dementia (BPSD)were assigned to BPSD group,and 37 patients without BPSD were assigned to control group. Neuropsychiatric Inventory (NPI ) was used to assess the severity of BPSD of all the participants and 5ml venous blood was drew from all the participants when they were admitted. The percentage and quantity of the monocytes was measured and recorded,and the same procedure was repeated after one month’s of therapy. The data were analyzed. Results The percentage of monocytes of BPSD group was higher than that of the control group when they were admitted[(8.56±0.92)vs(5.36±0.32);P<0.05] .In the BPSD group,both the NPI score[(26.49±6.17)vs(45.89±7.78);P<0.05]and the percentage of monocytes [(5.54±0.41)vs(8.56±0.92);P<0.05] decreased after they were treated for 1 month,but the percentage of monocytes after being treated was higher than that of control groups[(5.54±0.41)vs(5.33±0.33);P<0.05],while the the percentage of monocytes of control group didn’t change obviously (P>0.05). The percentage of monocytes of BPSD group before and after being treated was significantly associated with the NPI score (r=0.736,P<0.05;r=0.579,P<0.05). Conclusion The percentage of monocytes in peripheral blood of patients with AD was significantly associated with the NPI score.
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