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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
替普瑞酮联合法莫替丁防治抗血小板药物所致胃肠道损伤的效果观察
Therapeutic effect of teprenone combined with famotidine on gastrointestinal injury induced by antiplatelet drugs
投稿时间:2019-04-04  修订日期:2019-04-22
DOI:
中文关键词:  替普瑞酮;抗血小板药物;胃肠损伤
英文关键词:Teprenone; antiplatelet drug; gastrointestinal injury
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)
作者单位E-mail
陈振道 广东省化州市人民医院,消化内科 czd2043@sina.com 
陈浩 广东省人民医院,消化内科 124687fs1@qq.com 
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中文摘要:
      【摘要】目的:观察替普瑞酮联合法莫替丁防治抗血小板药物所致胃肠损伤的疗效。方法:选取我院2016年8月至2018年11月确诊为抗血小板药物所致胃肠损伤的患者84名。按随机数字表法分为三组,使用法莫替丁的为H2RA组,使用泮托拉唑为PPI组,联合使用替普瑞酮和法莫替丁的为联合组,三组均连续治疗六个月。观察三组的PGE2, TXB2,胃酸分泌量水平及改良Lanza评分。结果:经治疗后,联合组在PGE2,TXB2,胃酸分泌量和胃十二指肠粘膜损伤评分均有明显改善,差异具有统计学意义(P<0.05),除TXB2外,与其他两组比较,差异具有统计学意义(P<0.05)。结论:替普瑞酮联合法莫替丁防治抗血小板药物所致胃肠损伤的疗效显著且不良反应少,值得临床推广应用。
英文摘要:
      [Abstract] Objective:To observe the efficacy of teprenone combined with famotidine in preventing and treating gastrointestinal damage caused by antiplatelet drugs. Method:99 patients with gastrointestinal injuries caused by antiplatelet drugs were diagnosed in our hospital from August 2016 to November 2018.They were divided into three groups according to the random number table method, the halmotidine was used as the H2RA group, the pantoprazole was used as the PPI group, and the combination of teprenone and famotidine was used as the combination group, and three groups were treated for six months.Results:After treatment, the combination of PGE2, TXB2, gastric acid secretion and gastroduodenal mucosal injury scores were significantly improved, the difference was statistically significant (P <0.05), except for TXB2, compared with the other two groups, the difference Statistically significant (P < 0.05).Conclusion:The efficacy of teprenone combined with famotidine in the prevention and treatment of gastrointestinal damage caused by antiplatelet drugs is significant and has few adverse reactions, which is worthy of clinical application.
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