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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
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社区老年人群衰弱综合征危险因素的相关性研究
Risk factors of frailty syndrome in the elderly among community
投稿时间:2019-02-13  修订日期:2019-04-17
DOI:
中文关键词:  衰弱综合征;老年;慢性炎症;共病
英文关键词:frailty syndrome; elderly; chronic inflammation;comorbidity
基金项目:国家自然科学基金项目
作者单位E-mail
郭朝唤 空军军医大学西京医院 1057651838@qq.com 
侯莉明 空军军医大学西京医院 13319189560@163.com 
王晓明 空军军医大学西京医院 xmwang@fmmu.edu.cn 
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中文摘要:
      目的 衰弱综合征作为重要的老年综合征之一,其发病机制尚不清楚,本研究拟探讨社区老年人群衰弱综合征发生的可能危险因素。方法 对2017年10月至2018年10月西安市某社区卫生服务中心体检≥65岁老年人群进行横断面调查,运用FRAIL衰弱评估量表筛查纳入衰弱患者153人,并随机选取同期体检非衰弱老年人群174例。收集纳入老人的社会人口学资料、生活方式及疾病等相关资料,评估其衰弱状况,并检测其血清慢性炎症因子(TNF-α、CRP)水平。结果(1)与老年非衰弱组者相比,老年衰弱组患者血清中慢性炎症因子水平显著升高 [TNF-α: 19.38±1.51 ng/L vs 12.72±2.10 ng/L, CRP: 4.74±1.13 mg/L vs 3.39±0.58 mg/L, P<0.01];(2)相关性分析显示,衰弱组患者FRAIL综合积分与体重(r=0.129,P<0.05)、腰围(r=0.196,P<0.01)、BMI(r=0.135,P<0.05)、共病数量(r=0.621,P<0.01)、TNF-α(r=0.304,P<0.01)、CRP(r=0.596,P<0.01)间呈现显著性正相关关系;(3)多元逐步线性回归分析显示:老年人共病数量、慢性炎症水平(TNF-α、CRP)为老年人群衰弱综合征发生的独立危险因素(R2=0.507)。结论 社区老年人衰弱发生与患者超重、共病数量及慢性炎症因子水平密切相关。
英文摘要:
      Objective Frailty syndrome is an important geriatric syndrome, and its mechanism is still unclear. This study intends to explore the possible risk factors of the frailty syndrome in the elderly. Methods Using the FRAIL scale, 153 patients with FRAIL syndrome aged 65 years or older were screened from October 2017 to October 2018 in a community health service center in Xi’an, and 174 people with non-frail syndrome aged 65 years or older were selected at the same time. Socio-demographic, lifestyle and diseases of the elderly were collected, and the levels of inflammatory cytokines (TNF-α, CRP) in serum were detected by Elisa Kits. Results (1) The levels of chronic inflammation were significantly higher in the frailty group[TNF-α: 19.38±1.51 ng/L vs 12.72±2.10 ng/L; CRP: 4.74±1.13 mg/L vs 3.39±0.58 mg/L; P<0.01]; (2) The correlation analysis showed that the FRAIL group's integrated score was positively correlated with weight(r=0.129,P<0.05), waist (r=0.196,P<0.01), BMI(r=0.135,P<0.05), comorbidity(r=0.621,P<0.01), TNF-α(r=0.304,P<0.01), CRP(r=0.596,P<0.01); (3) Step-wise regression analysis showed that comorbidity, chronic inflammation (TNF-α, CRP) were the risk factors of frailty syndrome in elderly population (R2=0.507). Conclusion Overweight, comorbidity and the levels of chronic inflammation were the risk factors of frailty among the community elderly.
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