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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
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慢性心力衰竭患者血浆中FGF-23、Galectin-3水平与贫血的相关性研究
Study on the relationship between Plasma FGF-23, Galectin-3 levels and anemia in patients with chronic Heart failure
投稿时间:2019-06-05  修订日期:2019-06-28
DOI:
中文关键词:  慢性心力衰竭;贫血; FGF-23;Galectin-3
英文关键词:: chronic heart failure; anemia; FGF-23; Galectin-3
基金项目:
作者单位E-mail
王露朝 汉中市中心医院心血管内科 983298108@qq.com 
摘要点击次数: 35
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中文摘要:
      目的:贫血对心力衰竭患者的预后具有重要影响,本研究主要探讨慢性心力衰竭患者血浆FGF-23、Galectin-3水平与贫血的相关性。 方法:经过我院伦理委员会批准后,将我院2018年5月-2019年3月住院的慢性心力衰竭患者作为研究对象。排除恶心肿瘤、消化道出血、合并血液系统疾病及肾功能衰竭的患者后统一检测常规血液生化指标及血浆中FGF-23、Galectin-3的水平。以男性患者HB<120g/L为贫血组,女性患者HB<110g/L为贫血组。 结果:一共纳入研究95例患者,男性60例,女性35例,年龄68.4?4.28岁。其中贫血组47例,正常组48例。两组之间比较:FGF-23、Galectin-3、尿素氮、胱抑素C、肌酐具有显著性差异(334.83?50.84 pg/ml VS 256.3?64.6 pg/ml,t=6.58;48.79?12.32 pg/ml VS 42.04?10.16 pg/ml,t=2.91;9.7?4.15 mmol/L VS 7.12?2.70 mmol/L,t=3.60;1.6?0.86 mg/L VS 1.15?0.35 mg/L,t=3.3;97.96?38.82 umol/L VS 76.53?21.81; p<0.01)。相关性分析:HB与FGF-23、Galectin-3、尿素氮、胱抑素C水平、肌酐水平显著负相关(r=-0.470、-0.379、-0.330、-0.319,-0.282,p<0.01)。多因素logistic回归分析提示:FGF-23(OR=1.02, 95%CI1.01-1.03,P<0.01)、Galectin-3(OR=1.05, 95%CI1.004-1.102,P<0.05)、尿素氮(OR=1.235, 95%CI1.03-1.481,P<0.05)是贫血患者的独立危险因素。ROC曲线分析显示:FGF-23对贫血具有良好的预期价值。AUC=0.826,95%CI(0.742-0.909)。 结论:慢性心力衰竭患者血浆中FGF-23、Galectin-3水平与HB负相关;血浆中FGF-23、Galectin-3水平及尿素氮水平是慢性心力衰竭患者贫血的危险因素。
英文摘要:
      Objective: Anemia has an important impact on the prognosis of patients with heart failure. The purpose of this study was to investigate the correlation between plasma FGF-23 and Galectin-3 levels and anemia in patients with chronic heart failure. Methods: after the approval of the ethics committee of our hospital, the patients with chronic heart failure hospitalized in our hospital from May 2018 to March 2019 were taken as the subjects of the study. After excluding nausea tumor, gastrointestinal bleeding, patients with hematological diseases and renal failure, the routine blood biochemical indexes and the levels of FGF-23 and Galectin-3 in plasma were measured. Male patients with HB < 120g/L were used as anemia group and female patients with HB < 110g/L as anemia group. Results:A total of 95 patients, 60 males and 35 females, aged 68.4?4.28 years, were enrolled in the study. There were 47 cases of anemia group and 48 cases of normal group. Comparison between the two groups: there were significant differences in FGF-23, Galectin-3, urea nitrogen, cystatin C and creatinine between the two groups. (334.83?50.84 pg/ml VS 256.3?64.6 pg/ml,t=6.58;48.79?12.32 pg/ml VS 42.04?10.16 pg/ml,t=2.91;9.7?4.15 mmol/L VS 7.12?2.70 mmol/L,t=3.60;1.6?0.86 mg/L VS 1.15?0.35 mg/L,t=3.3;97.96?38.82 umol/L VS 76.53?21.81; p<0.01). Correlation analysis: HB was negatively correlated with FGF-23, Galectin-3, urea nitrogen, cystatin C and creatinine. (r=-0.470、-0.379、-0.330、-0.319,-0.282,p<0.01)。Multivariate logistic regression analysis suggested that: FGF-23(OR=1.02, 95%CI1.01-1.03,P<0.01)、Galectin-3(OR=1.05, 95%CI1.004-1.102,P<0.05)、Urea nitrogen(OR=1.235, 95%CI1.03-1.481,P<0.05)was an independent risk factor for anemia. ROC curve analysis showed that FGF-23 had a good diagnostic value for anemia. Conclusion: The levels of FGF-23 and Galectin-3 in plasma of patients with chronic heart failure ware negatively correlated with HB. Plasma levels of FGF-23, Galectin-3 and urea nitrogen ware independent risk factors for anemia in patients with chronic heart failure.
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