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中国人民解放军总医院老年心血管病研究所
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
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中国北方地区2型糖尿病患者摄盐量与NAFLD相关性研究
Association between salt intake and NAFLD in type 2 diabetes mellitus patients in North China
投稿时间:2019-05-16  修订日期:2019-06-20
DOI:
中文关键词:  摄盐量、尿钠、糖尿病,非酒精性脂肪性肝病
英文关键词:salt intake, Urine sodium, diabetes, NAFLD
基金项目:白求恩仁会糖尿病基金项目
作者单位E-mail
梁苡菲 哈尔滨医科大学附属第一医院内分泌二病房 liangyifei0726@126.com 
匡洪宇 哈尔滨医科大学附属第一医院内分泌科 ydyneifenmier@163.com 
秦文 哈尔滨医科大学附属第一医院内分泌科 2414658662@qq.com 
朱文博 哈尔滨医科大学附属第一医院内分泌科 hydyyzwb@163.com 
刘念娇 哈尔滨医科大学附属第一医院内分泌科 587000469@qq.com 
左姣 哈尔滨医科大学附属第一医院内分泌科 676311792@qq.com 
韩爽 哈尔滨医科大学附属第一医院内分泌科 440691222@qq.com 
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中文摘要:
      目的:本实验在中国北方的2型糖尿病(T2DM)患者中进行研究,探寻中国北方的2型糖尿病患者中摄盐量与NAFLD之间相关性。方法:选取哈尔滨医科大学附属第一医院内分泌科就诊的2型糖尿病患者(年龄18-69岁)978例。应用单因素及多因素logistic回归分析等对中国北方2型糖尿病患者中摄盐量与NAFLD是否存在相关性进行分析。结果:Spearman相关分析结果显示不同等级的摄盐量与2型糖尿病合并NAFLD存在相关性(r=0.129,P<0.001)。使用卡方检验比较不同组间NAFLD构成比的差异,差异具有统计学意义(x2=18.015,P<0.001)。在去除其他混杂因素后,BMI、HbA1c、空腹C肽、空腹血糖、摄盐量是2型糖尿病合并NAFLD的影响因素(P<0.05)。对性别、年龄、BMI、血糖、舒张压及收缩压进行亚组分析,在男性、年龄小于60岁、BMI≥24kg/m2,空腹血糖≥7.0mmol/L,收缩压≥130mmHg时,差异具有统计学意义(P<0.05)。结论:随着摄盐量的升高,中国北方2型糖尿病患者合并NAFLD的风险增大。在调整混杂因素后,中国北方人群2型糖尿病合并NAFLD与BMI、HbA1c、空腹C肽、空腹血糖、摄盐量存在相关性。
英文摘要:
      Background and Purpose:This study was conduct to explore the correlation between salt intake and NAFLD in T2DM patients in northern China.Methods:Our research choose the patients who live in the northeast of China for at least 6 months ,all the patients were diagnosed as T2DM and give treatment in The First Affiliated hospital of Harbin Medical University between 2016 to 2018. We use monofactor analysis and logistic regression analysis to assess the correlation between salt intake and NAFLD in T2DM patients.Results:Spearman correlation analysis shows that there was a correlation between different levels of salt intake and NAFLD in T2DM patients (r=0.129, P<0.001). The chi-square test was used to compare the NAFLD constituent ratio among the four groups, and the difference was statistically significant (x2=18.015, P < 0.001). In logistic regression analysis, BMI, HbA1c, fasting c-peptide, fasting blood glucose and salt intake was significantly associated with NAFLD in T2DM patients (P < 0.05). Subgroup analysis was performed on gender, age, BMI, blood glucose, systolic blood pressure. The difference was statistically significant in males, aged less than 60, with BMI≥24kg/m2, fasting blood glucose≥7.0mmol/L, and systolic blood pressure≥ 130mmHg (P < 0.05).Conclusion:With the increase of salt intake,T2DM patients in northern China were suffered from an increased risk of NAFLD. It shows that the occurrence of NAFLD was significantly correlated with BMI, HbA1c, fasting c-peptide, fasting blood glucose and salt intake.
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