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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
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不同肾功能水平及年龄段患者焦虑抑郁状况的调查
A survey of anxiety and depression status in patients on different renal function levels and age groups
投稿时间:2019-05-20  修订日期:2019-06-06
DOI:
中文关键词:  肾功能;增龄;焦虑;抑郁;汉密尔顿焦虑量表;汉密尔顿抑郁量表
英文关键词:renal function; aging; anxiety; depression; Hamilton anxiety rating scale; Hamilton depression rating scale
基金项目:江苏省医学重点学科项目(ZDXKA2016003);江苏省医学重点人才项目(ZDRCA2016021);江苏省“333工程”人才项目(BRA2017409);江苏省医学青年人才项目(QNRC2016592);江苏省干部保健科研课题(BJ17018, BJ16016)
作者单位E-mail
张宇 江苏省人民医院老年肾科 yuzhang1994@njmu.edu.cn 
赵卫红 江苏省人民医院老年肾科 zhaoweihongny@njmu.edu.cn 
雍珍珠 江苏省人民医院老年肾科 smileyzz0806@njmu.edu.cn 
裴小华 江苏省人民医院老年肾科 pxhphoto@njmu.edu.cn 
张娟 江苏省人民医院老年肾科 378711671@qq.com 
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中文摘要:
      目的 观察不同肾功能水平及年龄段住院患者的焦虑抑郁状况。方法 对266例2018年06月至2019年4月于江苏省人民医院老年医学科住院患者进行焦虑抑郁状况的评估。根据汉密尔顿焦虑量表评分结果分为:无(<7分)、轻度(7-14分)和中重度焦虑组(>14分);同理根据汉密尔顿抑郁量表分为:无(<7分)、轻度(7-17分)和中重度抑郁组(>17分)。结果 焦虑、抑郁组患者估算肾小球滤过率(eGFR)及血红蛋白(Hb)显著降低(P<0.05),且各组间差异有统计学意义。与无焦虑、抑郁组相比,轻度及中重度组患者的平均年龄均明显增加(P<0.01),组间呈上升趋势。不同程度焦虑抑郁症状患者的肾功能和年龄差异均有统计学意义(P<0.01)。多因素回归分析表明,肾功能下降(OR=1.26)、增龄(OR=2.01)和高血压(OR=1.82)是焦虑症状的危险因素;肾功能下降(OR=1.88)和增龄(OR=1.72)是抑郁症状的危险因素。相关性分析示,焦虑评分与抑郁评分之间显著正相关(P=0.000,r=0.719)。结论 肾功能下降和增龄是患者出现焦虑抑郁症状的独立危险因素。随着肾功能下降及年龄增加,不同程度焦虑抑郁症状的发生率均增加。
英文摘要:
      Objective To observe the anxiety and depression status of hospitalized patients on different renal function levels and age groups. Methods The anxiety and depression status of 266 patients hospitalized in geriatric department of Jiangsu Province Hospital from June 2018 to April 2019 were evaluated. According to Hamilton anxiety rating scale, the patients were divided into non-anxiety group (<7 points), mild anxiety group (7-14 points) and moderate-severe anxiety group (>14 points). In the same way, they were divided into non-depression group (<7 points), mild depression group (7-17 points) and moderate-severe depression group (>17 points) on the basis of Hamilton depression rating scale. Results The estimated glomerular filtration rate (eGFR) and hemoglobin (Hb) were significantly reduced in the anxiety and depression groups (P < 0.05), and the differences among groups were statistically significant. Compared with the non-anxiety or non-depression group, the age increased markedly in the mild and moderate-severe groups, and an upward trend could be found among groups (P<0.01). There were statistically significant differences both in renal function and age among patients in different conditions(P<0.01). Multivariate regression analysis revealed that degressive renal function (OR=1.26),aging (OR=2.01) and hypertension (OR=1.82) were risk factors for anxiety symptom. The risk factors of depression symptom included decreased renal function (OR=1.88) and aging (OR=1.72). Correlation analysis showed that there was a significantly positive correlation between anxiety and depression scores (P=0.000, r=0.719). Conclusion Decreased renal function and aging are independent risk factors for anxiety and depression in patients. With the decline of renal function and aging, the incidence of various levels of anxiety and depression symptoms increases.
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