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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
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轻度认知功能障碍与2型糖尿病及糖尿病前期的相关性研究
Correlation between mild cognitive impairment and type 2 diabetes and pre-diabetes
投稿时间:2019-05-09  修订日期:2019-07-16
DOI:
中文关键词:  轻度认知功能障碍; 2型糖尿病; 糖尿病前期
英文关键词:mild cognitive impairment ;type 2 diabetes ; pre-diabetes
基金项目:北京市和平里医院院级科研
作者单位E-mail
王琳 北京市和平里医院神经内科 13426412716@139.com 
李博 北京市和平里医院神经内科 13691089898@139.com 
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中文摘要:
      摘要:目的:探讨轻度认知功能障碍与2型糖尿病及糖尿病前期的相关性,旨 在为该类人群的早期干预提供科学依据。方法:选取2018年于北京市和平里医院就诊的年龄60-80岁的T2DM患者、IGR患者及非糖尿病受试者共120例,进行血糖、血脂情况、认知功能等调查并分析。结果:T2DM组MoCA评分低于IGR组(P<0.01)及非糖尿病组(P<0.01),IGR组MoCA评分低于非糖尿病组(P<0.05)。MoCA以26分为界诊断MCI时,T2DM组MCI发生率65%,显著高于非糖尿病组30% (P<0.01)。T2DM及IGR组患者发生MCI的多因素Logistic回归分析显示:两组的年龄、FBG和LDL是MCI的危险因素,OR值分别为1.104(1.026~1.132,P<0.05)、2.318(0.283~6.132,P<0.05)、3.382(1.613~8.206,P<0.05)和2.001(1.296~2.134,P<0.05)、0.986(0.010~2.488,P<0.01)、2.682(1.983~5.751,P<0.05);两组的受教育年限是MCI的保护性因素,OR值分别为1.688 (0.172~3.394,P<0.05)和1.692 (0.187~3.412,P<0.05)。结论:1. T2DM患者发生MCI的风险明显升高,这种趋势自IGR阶段就开始出现, 需关注IGR阶段的认知功能,及早干预,减缓老年痴呆的发生。2. T2DM及IGR患者的年龄、FBG和LDL是MCI的危险因素,受教育年限是MCI的保护性因素。
英文摘要:
      Abstract: Objective: To study the relationship between mild cognitive impairment and type 2 diabetes and pre-diabetes, in order to provide scientific basis for the early intervention of these groups. Methods: A total of 120 patients with T2DM、IGR and non-diabetes aged 60-80 years who visited Beijing Hepingli Hospital from January to December 2018 were enrolled in the study,and analyzed by the field survey method. Result: The MoCA score in T2DM was lower than that in IGR(P<0.01) and in non-diabetes(P<0.01), in IGR was lower than that in non-diabetes(P<0.05).And the MoCA score was 26 when the threshold value for the diagnosis of MCI was determined,the incidence of MCI was significantly higher in T2DM group(65%) than in non-diabetes group(30%)(P<0.01).Logistic regression analysis showed that age,FBG and LDL were risk factors for MCI in T2DM group and IGR group,its OR value was 1.104(1.026~1.132,P<0.05) 、2.318(0.283~6.132,P<0.05)、3.382(1.613~8.206,P<0.05) and 2.001(1.296~2.134,P<0.05)、0.986(0.010~2.488,P<0.001)、2.682(1.983~5.751,P<0.05);The years of schooling in both groups were protective factors of MCI,and OR value was 1.688 (0.172~3.394,P<0.05) and 1.692 (0.187~3.412,P<0.05). Conclusion: 1.The risk of MCI was significantly elevated in T2DM,a trend that began in the prophase of diabetes,and we should pay attention to the cognitive state of IGR state and conduct the early intervention in order to slow down the occurrence of senile dementia.2.Age,FBG and LDL in T2DM and IGR patients were risk factors for MCI,while education level was a protective factor for MCI.
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