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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
武海燕,马丽,张力,曹萌,张守字.园艺疗法对轻-中度阿尔茨海默病患者认知功能和生活质量的影响[J].中华老年多器官疾病杂志,2018,17(3):197~201
园艺疗法对轻-中度阿尔茨海默病患者认知功能和生活质量的影响
Effect of horticultural therapy on cognitive function and quality of life in patients with mild-to-moderate Alzheimer disease
投稿时间:2017-09-26  修订日期:2017-10-27
DOI:10.11915/j.issn.1671-5403.2018.03.043
中文关键词:  阿尔茨海默病;认知障碍;生活质量;园艺疗法
英文关键词:Alzheimer disease; cognitive disorders; quality of life; horticultural therapy
基金项目:
作者单位E-mail
武海燕 北京老年医院精神心理一科,北京 100095  
马丽 北京老年医院精神心理一科,北京 100095  
张力 北京老年医院精神心理一科,北京 100095  
曹萌 北京老年医院精神心理一科,北京 100095  
张守字 北京老年医院精神心理一科,北京 100095 lvye198100228@163.com 
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中文摘要:
      目的 评价园艺疗法(HT)对轻-中度阿尔茨海默病(AD)患者认知功能和生活质量的影响。方法 选取2014年12月至2016年12月北京老年医院住院部及门诊部轻-中度AD患者130例,随机分为对照组65例和HT组65例。对照组给予常规多奈哌齐联合尼麦角林口服治疗,HT组患者在常规治疗基础上,进行HT。分别于治疗前、治疗3个月和6个月时,使用简易精神状态评价量表(MMSE)和生活质量综合评定问卷(GQOL-74)对患者进行评估。采用SPSS 19.0软件对数据进行统计分析。根据数据类型,组间比较采用独立样本t检验或χ2检验,组内比较采用重复测量方差分析。结果 对照组治疗6个月MMSE总评分较治疗前显著升高,差异有统计学意义(P<0.05);HT组患者治疗3、6个月语言功能、记忆力、回忆力及MMSE总评分较治疗前均显著升高,差异有统计学意义(P<0.05)。与对照组比较,HT组患者3、6个月语言功能[(6.89±1.46) vs (5.21±2.36)分, (8.82±1.22) vs (6.80±1.49)分]、记忆力[(3.47±0.48) vs (2.04±0.65)分,(4.02±1.06) vs (2.92±0.86)分]、回忆力[(2.73±0.59) vs (1.03±0.78)分, (3.24±0.72) vs (2.24±0.92)分]及MMSE总评分[(20.82±1.35) vs (16.78±1.46)分, (24.02±2.20) vs (18.92±2.15)分]显著提高,差异有统计学意义(P<0.05)。HT患者治疗3、6个月社会功能、心理功能、躯体功能及GQOL-74总评分较治疗前均显著升高,差异有统计学意义(P<0.05);与对照组比较,HT组患者治疗3个月社会功能评分显著提高,差异有统计学意义[ (67.02±7.51) vs (63.28±9.52)分,P<0.05],治疗6个月社会功能[(69.33±6.94) vs (64.19±11.25)分]、心理功能[(57.12±13.07) vs (52.12±9.08)分]、躯体功能[(72.38±8.32) vs(66.85±10.08)分]及GQOL-74总评分[(68.46±9.34) vs (63.95±10.11)分]均明显升高,差异有统计学意义(P<0.05)。结论 HT联合常规药物治疗可能改善轻-中度AD患者认知功能,提高生活质量,具有重要的临床推广意义。
英文摘要:
      Objective To evaluate the effect of horticultural therapy (HT) on cognitive function and quality of life in elderly patients with mild-to-moderate Alzheimer disease (AD). Methods A total of 130 in- and out-patients with mild-to-moderate AD in our hospital from December 2014 to December 2016 were recruited and randomly divided into HT group and control group, with 65 cases in each group. The patients of control group was given conventional therapy, oral administration of donepezil combined with nicergoline, while those in the HT group received HT on the basis of conventional treatment. Mini-mental state examination (MMSE) and generic quality of life inventory-74(GQOL-74) were used to evaluate the patients before treatment and in 3 and 6 months after the treatment. SPSS statistics 19.0 was used for data processing. According to the data types, the independent sample Student’[KG-*3]s t test or the Chi-square test were used for the intergroup comparison, and repeated measurement of variance analysis was used for comparison between groups. Results The total score of MMSE in the control group was increased significantly after 6 months compared with the score before treatment (P<0.05). In the HT group, the scores of language function, remembrance, recall and the total MMSE score were significantly increased after 3 and 6 months’ treatment compared with those before treatment (P<0.05). Compared with the scores of control group in 3 and 6 months after treatment, the scores of language function [(6.89±1.46) vs (5.21±2.36), (8.82±1.22) vs (6.80±1.49)], remembrance [(3.47±0.48) vs (2.04±0.65), (4.02±1.06) vs (2.92±0.86)], recall[(2.73±0.59) vs (1.03±0.78), (3.24±0.72) vs (2.24±0.92)]and the total score of MMSE [(20.82±1.35) vs (16.78±1.46), (24.02±2.20) vs (18.92±2.15)] was significantly increased in the HT group (P<0.05). Social function, psychological function, physical function and total score of GQOL-74 were significantly improved in the HT group after 3 and 6 months than before treatment (P<0.05). Compared with the control group, the social function score in HT group was improved significantly after 3 months treatment [(67.02±7.51) vs (63.28±9.52), P<0.05], while after 6 months treatment, social function [(69.33±6.94) vs (64.19±11.25)], psychological function [(57.12±13.07) vs (52.12±9.08)], physical function [(72.38±8.32) vs (66.85±10.08)] and the total score of GQOL-74 [(68.46±9.34) vs (63.95±10.11)] were significantly increased (P<0.05). Conclusion HT can effectively improve the cognitive function and quality of life in the patients with mild-to-moderate AD, and it has an importance to be popularized clinically.
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