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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
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E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
胡振,张新超.低镁血症与老年急性心力衰竭90天不良预后的相关性[J].中华老年多器官疾病杂志,2018,17(6):438~441
低镁血症与老年急性心力衰竭90天不良预后的相关性
Correlation between hypomagnesemia and 90-day poor prognosis in elderly with acute heart failure
投稿时间:2018-01-11  修订日期:2018-02-20
DOI:10.11915/j.issn.1671-5403.2018.06.098
中文关键词:  急性心力衰竭;低镁血症;预后
英文关键词:acute heart failure; hypomagnesemia; prognosis
基金项目:
作者单位E-mail
胡振 北京医院急诊科,;国家老年医学中心,北京100730  
张新超 北京医院急诊科,;国家老年医学中心,北京100730 xinchaoz@163.com 
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中文摘要:
      目的 探讨低镁血症和老年急性心力衰竭(AHF)患者90 d不良预后的相关性。方法 入选2013年1月至2016年12月北京医院急诊科AHF患者150例,根据入院后90 d内是否发生终点事件分为预后不良组56例和非预后不良组94例,随访90 d终点事件为患者全因死亡或再次因AHF入院,分析影响患者预后的危险因素。应用SPSS 19.0统计软件对数据进行处理。组间比较采用t检验、Mann-Whitney U检验或χ2检验。单因素和多因素logistic回归分析筛选影响预后的危险因素。结果 90 d内终点事件发生率37.3%(56/150),其中因AHF再入院31.3%(47/150),死亡发生率6%(9/150)。预后不良组血镁水平明显低于非预后不良组[(0.70±0.05) vs (0.80±0.09)μmol/L],差异有统计学意义(P=0.000)。多因素logistic回归分析结果表明血镁水平降低[OR=30.631,95%CI 5.943~157.881;P=0.000]、呼吸频率增快[OR=1.354,95%CI 1.112~1.648;P=0.003]、临床床旁分级重型[OR=3.316,95%CI 1.169~9.403;P=0.024]、N末端脑钠肽前体(NT-proBNP)水平升高[OR=3.960,95%CI 1.318~11.892;P=0.014]为影响AHF患者90 d预后的独立危险因素。结论 低镁血症是老年AHF患者90 d不良预后的危险因素,其价值值得临床医师重视。
英文摘要:
      Objective To investigate the correlation of hypomagnesemia and 90-day poor prognosis in the elderly patients with acute heart failure (AHF). Methods A single center prospective trial was conducted on 150 elderly AHF patients admitted in the emergency department of Beijing Hospital between January 2013 and December 2016. According to the occurrence of endpoint events (all-cause mortality and re-hospitalization due to AHF) within 90 d after admission, they were divided into poor prognosis group (n=56) and non-poor prognosis group (n=94). SPSS statistics 19.0 was used to perform the statistical analysis. Student′s t test, Mann-Whitney U test or Chi-square test was employed for comparison between groups. Univariate and multivariate logistic regression analyses were adopted to screen the risk factors influencing the prognosis. Results The incidence rate of 90-day endpoint events were 37.3%(37/150), including 47 cases (31.3%) of re-hospitalization due to AHF and 9 cases (6.0%) of death. The serum magnesium level was significantly lower in the poor prognosis group than the non-poor prognosis group [(0.70±0.05) vs (0.80±0.09) μmol/L, P=0.000]. Multivariate logistic regression analysis indicated that lower magnesium level (OR=30.631,5%CI 5.943-157.881; P=0.000), rapider respiration rate (OR=1.354,5%CI 1.112-1.648; P=0.003), severer grade in bedside classification (OR=3.316, 95%CI 1.169-9.403; P=0.024) and elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) level (OR=3.960, 95%CI 1.318-11.892; P=0.014) were independent risk factors influencing 90-day prognosis of the AHF patients. Conclusion Hypomagnesemia is an independent risk factor for 90-day poor prognosis of elderly AFH patients, and clinicians should pay more attention to its value.
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