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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
王威,乌兰,聂皓,廖鹏志,李方达,刘端,赵瑜,张望德,卞策,党永康,郑月宏.迈之灵对下肢慢性静脉功能不全患者微循环的改善效果[J].中华老年多器官疾病杂志,2018,17(7):486~490
迈之灵对下肢慢性静脉功能不全患者微循环的改善效果
Effects of Aescuven forte on microcirculation for the treatment of chronic venous insufficiency
投稿时间:2018-01-15  修订日期:2018-02-23
DOI:10.11915/j.issn.1671-5403.2018.07.110
中文关键词:  下肢静脉功能不全;微循环;迈之灵
英文关键词:chronic venous insufficiency; microcirculation; aescuven forte
基金项目:国家自然科学基金面上项目(81470586;81770481);北京市自然科学基金面上项目(7172171);中国医学科学院医学与健康科技创新工程(2017-12M-1-008)
作者单位E-mail
王威 中国医学科学院北京协和医院血管外科,北京 100730  
乌兰 赤峰市医院血管外科, 赤峰 024000  
聂皓 中国医学科学院北京协和医院血管外科,北京 100730  
廖鹏志 中国医学科学院北京协和医院血管外科,北京 100730  
李方达 中国医学科学院北京协和医院血管外科,北京 100730  
刘端 中国医学科学院北京协和医院血管外科,北京 100730  
赵瑜 重庆医科大学附属第一医院血管外科,重庆 400016  
张望德 首都医科大学附属北京朝阳医院血管外科,北京 100043  
卞策 解放军火箭军总医院心脏大血管科, 北京 100088  
党永康 赤峰市医院血管外科, 赤峰 024000 dangyongkang@163.com 
郑月宏 中国医学科学院北京协和医院血管外科,北京 100730 yuehongzheng@yahoo.com 
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中文摘要:
      目的 分析迈之灵对下肢慢性静脉功能不全(CVI)患者微循环指标的改善情况。方法 入选2016年3月至2017年8月中国医学科学院北京协和医院和赤峰市医院血管外科门诊就诊的CVI患者40例,根据治疗方式分为迈之灵组23例和对照组17例。迈之灵组给予迈之灵及弹力袜治疗,对照组仅采用弹力袜治疗,疗程为4周。观察主要疗效指标[流行病学和经济研究(VEINES)/生活质量(QOL)/症状(Sym)问卷评分、经皮氧分压(TcPO2)、皮肤温度]、次要疗效指标(温控血流及阻断后反应性充血) 和不良反应, 并对疗效和安全性进行评估。采用SPSS 20.0统计软件进行数据处理及分析。组间比较采用t检验、Mann-Whitney U检验或χ2检验。结果 完成病例36例,迈之灵组22例,对照组14例。迈之灵组治疗前相比治疗后VEINES-QOL[(69.3±13.5) vs(76.7±11.9)分]、VEINES-Sym[(31.9±7.9) vs(36.0±7.4)分]、TcPO2[(45.2±22.3) vs(56.3±16.5)mmHg]、皮肤温度[32.6(31.5,3.9)℃ vs 31.8(31.0,2.9)℃]和温控血流[(151.4±123.0)% vs(418.0±179.5)%]差异均有统计学意义(P<0.05)。对照组治疗前相比治疗后VEINES-QOL[(64.0±16.1) vs(69.0±16.7)分]、VEINES-Sym[(29.3± 7.7) vs(32.6±7.9)分]和TcPO2[(39.6±16.8) vs(51.4±9.9)mmHg]差异有统计学意义(P<0.05)。迈之灵组相比对照组治疗前后的温控血流差值[(266.6±170.1)% vs(-110.1±160.5)%]差异有统计学意义(P<0.05)。结论 迈之灵在一定程度上可改善CVI患者生活质量及临床症状,其疗效可能与其对下肢微循环的改善作用有关。微循环指标中TcPO2、皮肤温度、温控血流可能在一定程度上反映CVI患者下肢微循环的变化。CVI的发病机制可能与下肢微循环改变有密切关联。
英文摘要:
      Objective To investigate the effects of Aescuven forte on microcirculation for the treatment of chronic venous insufficiency (CVI). Methods A total of 40 outpatients were enrolled in this study from Vascular Surgery Department of Peking Union Hospital and Chifeng Municipal Hospital from March 2016 to August 2017. They were divided into Aescuven forte group (n=23) and control group (n=17). In a course of 4 weeks, the former were treated with Aescuven forte and pressure (elastic stockings), while the latter only with pressure. Observation focused on the primary efficacy indicators [Venous Insufficiency Epidemiological and Economic Studies-quality of life/symptom score (VEINES-QOL/Sym), transcutaneous oxygen pressure (TcPO2) and skin temperature],secondary efficacy indicators [temperature-controlled blood blow and post-occlusion reactive hyperaemia (PORH)] and adverse reactions, and efficacy and safety were evaluated. SPSS statistics 20.0 was used to perform the statistical analysis. Student's t test, Mann-Whitney U test or Chi-square test was employed for comparison between two groups. Results Totally 36 patients (22 in the Aescuven forte group and 14 in the control group) finished the course of the treatment. The readings before vs. after treatment in the Aescuven forte group were VEINES-QOL [(69.3±13.5) vs(76.7±11.9) scores], VEINES-Sym [(31.9±7.9)vs(36.0±7.4)scores], TcPO2[(45.2±22.3) vs(56.3±16.5)mmHg], skin temperature [32.6(31.5,33.9)℃ vs 31.8(31.0,2.9)℃] and the temperature-controlled blood flow [(151.4±123.0)% vs(418.0±179.5)%], and the differences were statistically significant (P<0.05). The readings before vs. after treatment in the control group were VEINES-QOL [(64.0±16.1) vs(69.0±16.7)scores], VEINES-Sym [(29.3±7.7) vs(32.6±7.9)scores], and TcPO2 [(39.6±16.8) vs(51.4±9.9)mmHg], and the differences were statistically significant (P<0.05). Significant difference was observed in temperature-controlled blood flow between two groups[(266.6±170.1)% vs(-110.1±160.5)%, P<0.05]. Conclusion Our findings indicated that Aescuven forte may improve the quality of life and relieve the symptoms of the patients with CVI, and that a correlation could be established between curative effects and the improved microcirculation. Parameters such as TcPO2, skin temperature, temperature-controlled blood flow may indicate the changes of microcirculation, implying a relation between the pathogenesis of CVI and the alteration of microcirculation.
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