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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
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武钰翔,顾洪斌,朱平,石鸿雁,宁丹,王爱红.临床氧化应激指标与糖尿病周围神经病变的相关研究[J].中华老年多器官疾病杂志,2018,17(8):573~577
临床氧化应激指标与糖尿病周围神经病变的相关研究
Correlation between clinical oxidative stress and diabetic peripheral neuropathy
投稿时间:2018-05-03  修订日期:2018-06-18
DOI:10.11915/j.issn.1671-5403.2018.08.131
中文关键词:  2型糖尿病;氧化应激;糖尿病周围神经病变
英文关键词:type 2 diabetes mellitus; oxidative stress; diabetic peripheral neuropathy
基金项目:
作者单位E-mail
武钰翔 解放军第306医院内分泌科,北京 100101  
顾洪斌 解放军第306医院血管外科,北京 100101  
朱平 解放军第306医院内分泌科,北京 100101  
石鸿雁 解放军第306医院内分泌科,北京 100101  
宁丹 解放军第306医院内分泌科,北京 100101  
王爱红 解放军第306医院内分泌科,北京 100101 13671365441@139.com 
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中文摘要:
      目的 调查2型糖尿病患者的临床氧化应激指标情况,分析其与2型糖尿病患者伴发周围神经病变的相关性。方法 收集2016年10月至2017年5月解放军第306医院内分泌科同期住院的212例2型糖尿病患者一般资料及临床资料。根据2型糖尿病患者伴发周围神经病变诊断标准,将入选患者分为伴发周围神经病变(n=97)和未伴发周围神经病变(n=115)2组。应用SPSS 23.0对2组患者的一般情况及临床资料进行比较,采用logistic 回归分析2型糖尿病患者伴发周围神经病变的危险因素。探讨2型糖尿病患者伴发周围神经病变的特点及其与临床氧化应激指标的相关性。结果 2型糖尿病患者伴发周围神经病变组患者年龄、病程、糖化血红蛋白、总胆固醇显著高于未伴发周围神经病变组患者,空腹C肽、血红蛋白和总胆红素显著低于2型糖尿病非周围神经病变组患者(P<0.05)。单因素logistic回归分析显示年龄、病程、糖化血红蛋白、总胆红素、血红蛋白可能与2型糖尿病患者伴发周围神经病变相关,进一步多因素logistic回归分析显示病程(OR=1.006,95%CI 1.003~1.010)、糖化血红蛋白(OR=1.403,95%CI 1.118~1.657)、血红蛋白(OR=0.976,95%CI 0.958~0.994)是2型糖尿病患者伴发周围神经病变的独立危险因素。结论 2型糖尿病患者伴发周围神经病变患者临床氧化应激指标(总胆红素、血红蛋白)低于2型糖尿病非周围神经病变患者,且具有高龄、糖尿病病程长、血糖控制不佳及胰岛功能差的特点。
英文摘要:
      Objective To investigate the relationship between diabetic peripheral neuropathy and clinical indicators of oxidative stress in the patients with type 2 diabetes mellitus. Methods General and clinical data were collected of patients hospitalized from 2016 to 2017 with type 2 diabetes mellitus in our hospital. The patients were divided into group A with peripheral neuropathy (n=97) and group B (n=115) without. The two groups were compared in general and clinical data using SPSS statistics 23.0, and logistic regression was employed to analyze the risk factors for diabetic peripheral neuropathy. The characteristics of diabetic peripheral neuropathy and its correlation with clinical indicators of oxidative stress were investigated. Results The age, disease duration, glycosylated hemoglobin A1c and total cholesterol were significantly higher in group A than in group B, while fasting C peptide, hemoglobin and total bilirubin was significantly lower in the former than in the latter (P<0.05). The univariate logistic regression model revealed that age, disease duration, glycosylated hemoglobin A1c, total bilirubin and hemoglobin might be associated with diabetic peripheral neuropathy. The multivariate logistic regression analysis showed that disease duration (OR=1.006,95%CI 1.003-1.010), glyco-sylated hemoglobin A1c (OR=1.403,95%CI 1.118-1.657), hemoglobin (OR=0.976,95%CI 0.958-0.994) were significant risk factors for diabetic peripheral neuropathy. Conclusion Patients with diabetic peripheral neuropathy have lower clinical indicators of oxidative stress (total bilirubin and hemoglobin) than those without, the former being more advanced in age, having long duration of diabetes, poorer blood glucose control, and poorer islet function.
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