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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
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E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
陈瑜,杨龙.热疗对食管癌患者的辅助治疗作用及其对血清糖类抗原199及血管内皮生长因子的影响[J].中华老年多器官疾病杂志,2018,17(9):677~681
热疗对食管癌患者的辅助治疗作用及其对血清糖类抗原199及血管内皮生长因子的影响
Supportive therapeutic efficacy of hyperthermia in patients with esophageal cancer and its effects on serum carbohydrate antigen 199 and vascular endothelial growth factor
投稿时间:2018-03-23  修订日期:2018-06-29
DOI:10.11915/j.issn.1671-5403.2018.09.155
中文关键词:  食管癌;治疗效果;血管内皮生长因子;糖类抗原199;热疗
英文关键词:esophageal cancer; therapeutic efficacy; vascular endothelial growth factor; carbohydrate antigen 199; hyperthermia
基金项目:
作者单位E-mail
陈瑜 宝鸡市人民医院 胸外科,宝鸡 721000  
杨龙 宝鸡市人民医院急诊外科,宝鸡 721000 ylymf@126.com 
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中文摘要:
      目的 探讨热疗对食管癌患者的辅助治疗作用及其对血清糖类抗原199(CA199)及血管内皮生长因子(VEGF)的影响。方法 选取2012年9月至2016年9月宝鸡市人民医院胸外科收治的食管癌患者100例,依据随机数字表法将患者分为热疗组和对照组,每组50例。对照组给予多西他赛+奈达铂化疗治疗及常规放射疗法,热疗组在对照组方案基础上给予热疗辅助治疗。比较2组患者血清CA199、VEGF水平及治疗疗效、不良反应及生存情况。采用SPSS 22.0统计软件对数据进行分析。根据数据类型,组间比较采用t检验、χ2检验或秩和Z检验,组内比较采用自身配对t检验。对生存预后采用Kaplan-Meier曲线分析。结果 热疗组患者治疗有效率明显高于对照组,差异有统计学意义[90.00%(45/50) vs 74.00%(37/50),P=0.04]。2组患者治疗后血清CA199及VEGF水平均明显低于治疗前,且热疗组患者治疗后血清CA199[(50.42±5.54) vs (76.45±7.72)U/ml]及VEGF[(137.2±15.5) vs (203.5±24.0)pg/ml]水平明显低于对照组,差异有统计学意义(P<0.01)。2组患者不良反应发生率比较,差异无统计学意义(P=0.46);随访2年,热疗组治疗生存率明显高于对照组,差异有统计学意义[60.00%(30/50) vs 40.00%(20/50),P=0.03]。结论 在传统化疗及放射治疗基础上,热疗可有效提高食管癌患者的治疗疗效,改善生存情况,具有良好的安全性,值得临床进一步推广。
英文摘要:
      Objective To investigate supportive therapeutic efficacy of hyperthermia in patients with esophageal cancer and its effect on the level of serum carbohydrate antigen 199 (CA199) and vascular endothelial growth factor (VEGF). Methods Included in the study were 100 patients with esophageal cancer who attended the Department of Thoracic Surgery of Baoji People′s Hospital from September 2012 to September 2016. They were randomized into hyperthermia group and control group, with 50 cases in each group. The control group was given chemotherapy with docetaxel+nedaplatin and conventional radiotherapy, and the hyperthermia group were given hyperthermia in addition to the treatment for the control group. The two groups were compared in the level of serum CA199, VEGF and therapeutic efficacy, adverse reactions, and survival rates. SPSS statistics 22.0 was used for data analysis. Depending on data type, Student′s t test, Chi-square test or rank-sum test was used for comparison between groups, the paired t-test for comparison within the group, and Kaplan-Meier curve analysis for survival prognosis. Results The efficacy was higher in the hyperthermia group than in the control group, with significant difference [90.00%(45/50) vs 74.00%(37/50), P=0.04]. The serum level of CA199 and VEGF in both groups were significantly lower after treatment than those before treatment, and the serum level of CA199 [(50.42±5.54) vs (76.45±7.72)U/ml] and VEGF [(137.2±15.5) vs (203.5±24.0)pg/ml] after treatment were significantly lower in the hyperthermia group than those in the control group, the differences being statistically significant (P<0.01). No statistically significant difference was observed in the incidence of adverse reactions between the two groups (P=0.46). During 2-year follow-up, the survival rate in the hyperthermia group was significantly higher than that in control group [60.00%(30/50) vs 40.00%(20/50), P=0.03]. Conclusion Hyperthermia can effectively enhance the therapeutic efficacy of the conventional chemo-therapy and radiotherapy in esophageal cancer patients with increased survival and satisfactory safety. It is worthy of further promotion in clinical practice.
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