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中国人民解放军总医院
主 办
中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
刘洋,于文娟,李秀珍,赵蓓,姚刚.高龄原发性高血压患者合并慢性肾脏病的危险因素[J].中华老年多器官疾病杂志,2019,18(1):1~5
高龄原发性高血压患者合并慢性肾脏病的危险因素
Risk factors for essential hypertension complicated with chronic kidney disease in ≥80 years old patients
投稿时间:2018-09-26  修订日期:2018-10-18
DOI:10.11915/j.issn.1671-5403.2019.01.001
中文关键词:  老年人,80以上;高血压;慢性肾脏病;危险因素
英文关键词:aged, 80 and over; hypertension; chronic kidney disease; risk factor
基金项目:江苏省卫生厅指导性科研项目(Z201204);“六大人才高峰”D类资助项目(2014-WSN-020)
作者单位E-mail
刘洋 南京医科大学第二附属医院 肾内科,南京 210011  
于文娟 南京医科大学第二附属医院 肾内科,南京 210011  
李秀珍 南京医科大学第二附属医院心血管内科,南京 210011  
赵蓓 南京医科大学第二附属医院 肾内科,南京 210011  
姚刚 南京医科大学第二附属医院 肾内科,南京 210011 yg921@163.com 
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中文摘要:
      目的 了解80岁以上原发性高血压(EH)住院患者合并慢性肾脏病(CKD)的情况,分析相关危险因素。方法 选取南京医科大学第二附属医院心血管内科住院的1 555例65岁以上EH患者,依据是否≥80岁分为2组:高龄组(n=575)和非高龄组(n=980)。收集患者的临床资料。采用SPSS 22.0软件进行数据处理,logistic回归分析EH合并CKD的危险因素。结果 与非高龄EH组患者比较,高龄EH组患者CKD发生率显著升高(52.9% vs 29.5%,P<0.05)。高龄EH患者合并CKD的危险因素依次为高尿酸血症(OR=2.514,95%CI 1.750~3.611;P<0.001)、年龄(OR=1.072,95%CI 1.018~1.129;P=0.009)和收缩压(OR=1.019,95%CI 1.011~1.028;P<0.001),保护因素为高密度脂蛋白胆固醇(OR=0.516,95%CI 0.315~0.847;P=0.009);非高龄老年EH患者合并CKD的危险因素依次为高尿酸血症(OR=2.729,95%CI 1.991~3.740;P<0.001)、糖尿病(OR=1.944,95%CI 1.420~2.662;P<0.001)、年龄(OR=1.140,95%CI 1.101~1.182;P<0.001)和收缩压(OR=1.009,95%CI 1.003~1.016;P=0.007),保护因素为高密度脂蛋白胆固醇(OR=0.448,95%CI 0.278~0.722;P=0.001)。结论 高龄老年EH患者合并CKD的比例显著高于非高龄老年EH患者,高龄EH患者合并CKD与高尿酸血症、年龄、收缩压及高密度脂蛋白胆固醇水平有关。
英文摘要:
      Objective To analyze the risk factors for chronic kidney disease (CKD) complication in essential hypertension (EH) patients ≥80 years of age. Methods A total of 1 555 elderly EH patients aged over 65 years old admitted to our department during March 2014 and June 2017 were enrolled in this study. They were assigned into ≥80-year-old group (n=575) and <80-year-old group (n=980). Their clinical data were collected and analyzed. SPSS statistics 22.0 was used to analyze the data, and logistic regression analysis was employed to identify the risk factors for CKD. Results Compared with <80-year-old group, ≥80-year-old group had significantly higher incidence of CKD (52.9% vs 29.5%, P<0.05). In ≥80-year-old EH patients, the risk factors for CKD were hyperuricemia (OR=2.514, 95%CI 1.750-3.611; P<0.001), age (OR=1.072,5%CI 1.018-1.129; P=0.009) and systolic blood pressure (OR=1.019,5%CI 1.011-1.028; P<0.001), and the protective factor was high-density lipoprotein cholesterol (OR=0.516, 95%CI 0.315-0.847; P=0.009). While, for <80-year-old EH patients, the risk factors were hyperuricemia (OR=2.729, 95%CI 1.991-3.740; P<0.001), diabetes mellitus (OR=1.944,5%CI 1.420-2.662; P<0.001), age (OR=1.140, 95%CI 1.101-1.182; P=0.009) and systolic blood pressure (OR=1.009,5%CI 1.003-1.016; P=0.007), and the protective factor was high-density lipoprotein cholesterol (OR=0.448,5%CI 0.278-0.722; P=0.001). Conclusion The incidence rate of CKD in ≥80-year-old EH patients is obviously higher than that in <80-year-old EH patients. The complication of CKD is associated with age, hyperuricemia, systolic blood pressure and high-density lipoprotein cholesterol in ≥80-year-old EH patients.
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