在线办公
期刊论坛
主 管
中国人民解放军总医院
主 办
中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
季红莉,路琴,黄慧,陈明,张汾燕,谢瑞华,付万发.老年患者幽门螺杆菌感染根除失败的原因[J].中华老年多器官疾病杂志,2019,18(1):26~29
老年患者幽门螺杆菌感染根除失败的原因
Causes of failed eradication of Helicobacter pylori infection in the elderly patients
投稿时间:2018-10-05  修订日期:2018-11-08
DOI:10.11915/j.issn.1671-5403.2019.01.006
中文关键词:  老年人;螺杆菌,幽门;根除;失败
英文关键词:aged; Helicobacter pylori; eradication; failure
基金项目:
作者单位E-mail
季红莉 北京老年医院消化科,北京 100095  
路琴 北京老年医院消化科,北京 100095  
黄慧 北京老年医院消化科,北京 100095  
陈明 北京老年医院消化科,北京 100095  
张汾燕 北京老年医院消化科,北京 100095  
谢瑞华 北京老年医院消化科,北京 100095  
付万发 北京老年医院消化科,北京 100095 fafangyu@163.com 
摘要点击次数: 63
全文下载次数: 82
中文摘要:
      目的 探讨老年患者幽门螺杆菌(Hp)感染根除失败的原因。方法 收集2017年1月至2018年6月期间在北京老年医院接受Hp根除治疗的年龄≥60岁患者200例。根除治疗完全停止后1个月以上复查碳13呼气试验,以根除失败者为研究组,共计36例患者Hp阳性。选取同期根除成功的40例患者为对照组。应用自制调查问卷调查所有患者一般社会状况、消化系统疾病、既往病史、是否多重用药、吸烟、饮酒、不良反应发生、根除方案、依从性、根除前是否服用抗生素、根除前是否服用质子泵抑制剂(PPI)以及Hp根除意愿。采用SPSS 17.0软件进行数据处理。依据数据类型,组间比较分别采用t检验或χ2检验。logistic回归分析Hp根除失败的危险因素。结果 多重用药(OR=0.102,95%CI 0.025~0.419;P=0.002)、依从性(OR=0.112,95%CI 0.016~0.779;P=0.027)、根除前是否服用PPI(OR=5.903,95%CI 1.193~29.215;P=0.030)和是否采用阿莫西林四联方案(OR=0.095,95%CI 0.012~0.744;P=0.025)与Hp根除成功与否独立相关。结论 老年患者Hp感染应个体化、规范化治疗。
英文摘要:
      Objective To investigate the causes of the failed eradication of Helicobacter pylori(Hp)infection in the elderly. Methods Data were collected of 200 patients aged 60 years or older who underwent Hp eradication in Beijing Geriatric Hospital from January 2017 to June 2018. A carbon 13 breath test was performed on the follow-up visit at 1 month after the completion of the eradication treatment, 36 patients who failed in the eradication with positive Hp were taken as study group, and 40 patients who were selected from those with successful eradication as control group. Using a self-developed questionnaire, data were collected of their social status, digestive diseases, past medical history, multiple drugs use, smoking, alcohol consumption, adverse reactions, eradication protocols, compliance, taking antibiotics or proton pump inhibitor (PPI) before eradication, and willingness for eradication. Data were processed with SPSS statistics 17.0. Depending on data type, t-test or χ2 test was used for comparison. Logistic regression was performed for the analysis of risk factors for the failure of Hp eradication. Results Multiple drugs use (OR=0.102,5%CI 0.025-0.419; P=0.002), compliance (OR=0.112,95%CI 0.016-0.779; P=0.027), and taking PPI (OR=5.903,5%CI 1.193-29.215; P=0.030) or bismuth-based quadruple regimen with amoxicillin(OR=0.095,5%CI 0.012-0.744; P=0.025) before the eradication were independently associated with success of Hp eradication. Conclusion The treatment of Hp infection in the elderly should be individualized and standardized.
查看全文    下载PDF阅读器
关闭