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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
李文金,张先俊,余世界.老年胃癌患者缺氧诱导因子-1α及-2α的表达及其临床意义[J].中华老年多器官疾病杂志,2019,18(4):290~294
老年胃癌患者缺氧诱导因子-1α及-2α的表达及其临床意义
Expression of hypoxia inducible factor-1-alpha and -2-alpha in elderly patients with gastric cancer and its clinical significance
投稿时间:2018-11-22  
DOI:10.11915/j.issn.1671-5403.2019.04.059
中文关键词:  老年人;胃癌;缺氧诱导因子;病理;影响因素
英文关键词:aged; gastric cancer; hypoxia inducible factor; pathology; influencing factors
基金项目:
作者单位E-mail
李文金 湖北省第三人民医院阳逻院区消化内科,武汉 430415 2356960239@qq.com 
张先俊 .潜江市中心医院消化内科,武汉 433199  
余世界 .武汉大学人民医院消化内科,武汉 430060  
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中文摘要:
      目的 观察老年胃癌患者缺氧诱导因子-1α(HIF-1α)及HIF-2α的表达情况,并分析其临床意义。方法 选取2017年2月至2018年3月期间在湖北省第三人民医院阳逻院区接受治疗的老年胃癌患者100例,同时选取同期在我院接受胃镜检查的健康老年人(≥65岁)100名作为对照组。免疫组织化学检测2组研究对象HIF-1α及HIF-2α的表达情况。采用SPSS 17.0软件进行数据处理。依据数据类型,组间比较分别采用t检验或χ2检验。多因素logistic回归分析筛选出影响胃癌患者HIF-1α及HIF-2α表达的独立危险因素。结果 胃癌组患者的HIF-1α(85.0% vs 8.0%)及HIF-2α(82.0% vs 5.0%)阳性表达率均显著高于对照组(P<0.001)。多因素logistic回归分析结果显示,淋巴结转移情况(HIF-1α:OR=5.132,95%CI 1.872~14.325,P=0.008;HIF-2α:OR=4.629,95%CI 1.754~16.392,P=0.002)和临床分期(HIF-1α:OR=3.957,95%CI 1.694~8.363,P=0.012;HIF-2α:OR=4.341,95%CI 2.312~10.052,P=0.010)是影响胃癌患者HIF-1α及HIF-2α阳性表达的独立危险因素。结论 老年胃癌患者HIF-1α和HIF-2α阳性表达率较高,且受临床分期和淋巴结转移情况的影响。
英文摘要:
      Objective To measure the expression of hypoxia inducible factor-1-alpha (HIF-1α) and hypoxia inducible factor-2-alpha (HIF-2α) in the elderly patients with gastric cancer and to analyze its clinical significance. Methods A total of 100 elderly patients with identified gastric cancer treated in the Yangluo Branch from February 2017 to March 2018 were enrolled as the study subjects, and another 100 healthy old individuals (over 65 years old) who received gastroscopy in our branch during the same period were recruited as the control group. The expression of HIF-1α and HIF-2α was detected in the 2 groups. SPSS statistics 17.0 was used to perform the statistical analysis. Student′s t test or Chi-square test was applied for comparison between groups in difference data types. Multivariate logistic regression analysis was employed to screen the independent influencing factors for the expression of the 2 proteins in the patients. Results The positive expression rates of HIF-1α (85.0% vs 8.0%) and HIF-2α (82.0% vs 5.0%) in gastric cancer group were significantly higher than those in control group (P<0.001). Multivariate logistic regression analysis indicated that lymph node metastasis (HIF-1α:OR=5.132,5%CI 1.872-14.325, P=0.008; HIF-2α:OR=4.629, 95%CI 1.754-16.392; P=0.002) and clinical stage (HIF-1α:OR=3.957,5%CI 1.694-8.363, P=0.012; HIF-2α:OR=4.341,5%CI 2.312-10.052, P=0.010) were independent risk factors for the positive expression of HIF-1α and HIF-2α in gastric cancer patients. Conclusion The elderly patients with gastric cancer have higher positive expression rate of HIF-1α and HIF-2α, which may be related with clinical stage and lymph node metastasis.
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