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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
金凤钟,曹桂花,刘艳,王晓明,宁晓暄.亚临床甲状腺功能减退症与绝经后女性骨代谢指标的相关性分析[J].中华老年多器官疾病杂志,2019,18(10):743~746
亚临床甲状腺功能减退症与绝经后女性骨代谢指标的相关性分析
Correlation between subclinical hypothyroidism and bone mineral density in postmenopausal women
投稿时间:2019-06-04  
DOI:10.11915/j.issn.1671-5403.2019.10.161
中文关键词:  骨质疏松, 绝经后;骨密度;亚临床甲状腺功能减退症
英文关键词:osteoporosis, postmenopausal; bone density; subclinical hypothyroidism This work was supported by the Discipline-Promotion Program of Xijing Hospital
基金项目:西京医院学科助推计划(XJZT18MDT11)
作者单位E-mail
金凤钟 空军军医大学西京医院老年病科,西安 710032  
曹桂花 空军军医大学西京医院老年病科,西安 710032  
刘艳 空军军医大学西京医院老年病科,西安 710032  
王晓明 空军军医大学西京医院老年病科,西安 710032  
宁晓暄 空军军医大学西京医院老年病科,西安 710032 ningxx01@fmmu.edu.cn 
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中文摘要:
      目的 探讨亚临床甲状腺功能减退症(SCH)与绝经后女性骨密度及骨代谢相关指标的关系。方法 选取2015年1月至2018年6月在空军军医大学西京医院老年病科就诊的138例绝经后女性临床资料,根据患者是否患SCH分为SCH组(68例)和正常对照组(70例)。检测并比较2组患者骨密度相关指标[碱性磷酸酶(ALP)、Ca2+、骨化三醇、骨密度T值(T <-1.0为骨密度异常)]以及甲状腺功能相关指标[甲状旁腺激素(PTH)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb+)比例]。采用SPSS 18.0统计软件对数据进行分析。相关性采用Spearman相关分析。结果 SCH组及对照组患者骨密度异常率分别为50.0%(34/68)和25.7%(18/70),2组比较差异有统计学意义(P=0.003)。与对照组比较,SCH组患者TSH水平和TPOAb+比例显著升高(P<0.05),但FT3、FT4、PTH及骨代谢相关指标比较,差异无统计学意义(P>0.05)。Spearman相关分析显示,TSH、TPOAb+与ALP、骨化三醇、骨密度T值呈负相关,其中TSH与T值呈高度负相关(r =-0.804,P<0.01)。结论 SCH可能引起绝经后女性骨量异常和骨密度测定值降低,这可能与血清TSH水平升高和TPOAb呈阳性有关。
英文摘要:
      Objective To investigate the correlation between subclinical hypothyroidism (SCH) and bone mineral density and markers of bone metabolism in postmenopausal women. Methods The clinical data were collected of 138 postmenopausal women treated in Xijing Hospital of Air Force Medical University from January 2015 to June 2018, who were divided into SCH group (n=68) and control group with normal thyroid function (n=70). The two groups were examined for some biochemical markers and bone mineral density and were compared in the indices of bone metabolism including alkaline phosphatase (ALP), Ca2+, calcitriol [25-(OH)D3] and bone mineral density T value (T<-1.0 stands for abnormal bone mineral density), and thyroid function related indices including parathormone (PTH), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), thyroxine (FT4) and positive rate of thyroid peroxidase antibody (TPOAb+). SPSS statistics 18.0 was used for data analysis. Results The abnormal rates of bone mineral density in SCH group and control group were 50.0%(34/68) and 25.7%(18/70), with significant difference between the two groups (P=0.003). Compared with the control group, TSH level and TPOAb+ ratio in SCH group increased significantly (P<0.05), but there were no significant differences in FT3, FT4, PTH and bone metabolism related indices (P>0.05). Spearman correlation analysis showed that TSH and TPOAb+ ratio were negatively correlated with ALP, 25-(OH)D3 and T values, and TSH was highly negatively correlated with T values (r=-0.804, P<0.01). Conclusion SCH may cause abnormal bone mass and decrease of bone mineral density in postmenopausal women, which is probably related to the increased serum TSH level and the positive TPOAb.
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