在线办公
期刊论坛
主 管
中国人民解放军总医院
主 办
中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
诸国华,孙希鹏,李静,皮林,唐海沁,高海青,丛洪良,曲鹏,卢新政,张新军,赵洛沙,郭艺芳,刘东霞,张亮清,唐桦,华琦,范利.复方利血平氨苯蝶啶片治疗老年高血压患者有效性和安全性的全国多中心调查研究结果与分析[J].中华老年多器官疾病杂志,2019,18(10):758~764
复方利血平氨苯蝶啶片治疗老年高血压患者有效性和安全性的全国多中心调查研究结果与分析
Efficacy and safety of compound reserpine and amphetamine tablets for the treatment of hypertension in the elderly patients:results from a national multi-center study
投稿时间:2019-06-27  
DOI:10.11915/j.issn.1671-5403.2019.10.164
中文关键词:  老年人;高血压;复方血平氨苯蝶啶片;安全性
英文关键词:aged; hypertension; compound reserpine and amphetamine tablets; safety Corresponding author:FAN Li, E-mail:fl6698@163.com; HUA Qi, E-mail:huaqi5371@sina.com〖FL
基金项目:
作者单位E-mail
诸国华 首都医科大学宣武医院心血管内科,北京 100053  
孙希鹏 首都医科大学宣武医院心血管内科,北京 100053  
李静 首都医科大学宣武医院心血管内科,北京 100053  
皮林 清华大学附属北京市垂杨柳医院心血管内科,北京 100022  
唐海沁 安徽医科大学第一附属医院老年病科,合肥 230022  
高海青 山东大学齐鲁医院干部保健科,济南 250012  
丛洪良 天津市胸科医院心血管内科,天津 300051  
曲鹏 大连医科大学附属第二医院心血管内科,大连 116027  
卢新政 江苏省人民医院心血管内科,南京 210029  
张新军 四川大学华西医院老年病科,成都 610041  
赵洛沙 郑州大学第一附属医院心血管内科,郑州450052  
郭艺芳 河北省人民医院老年病科,石家庄 050057  
刘东霞 河北省人民医院心血管内科,石家庄 050057  
张亮清 山西省心血管病医院心血管内科,太原 030024  
唐桦 首都医科大学宣武医院心血管内科,北京 100053  
华琦 首都医科大学宣武医院心血管内科,北京 100053 huaqi5371@sina.com 
范利 国家老年疾病临床医学研究中心,北京 100853 fl6698@163.com 
摘要点击次数: 59
全文下载次数: 58
中文摘要:
      目的 比较复方利血平氨苯蝶啶片(0号)与其他降压药物治疗老年高血压患者的有效性和安全性。方法 入选2018年8月至2018年12月期间就诊于天津、河南、安徽、山东、江苏、山西、四川、辽宁、北京、河北10个省市共26家社区卫生服务中心的老年高血压患者1574例。根据是否服用0号(按年龄差≤5岁及性别1∶1进行配对),分为0号组和非0号组,每组787例。1574例患者中,高龄(≥80岁)患者共186例,依据是否服用0号分为2个亚组:高龄0号组(n=102)和高龄非0号组(n=84)。对比2组患者所有临床资料及2个亚组患者的实验室指标及精神状态评分。采用SPSS 22.0软件进行统计分析。结果 2组研究对象的高血压分级和诊室血压差异无统计学意义(P>0.05)。0号组患者每天服用的降压药物片数显著少于非0号组患者[(1.33±0.63)和(1.41±0.63)片,P<0.05],服用钙离子通道阻滞剂(16.39%和70.14%)、血管紧张素转化酶抑制剂(4.07%和11.82%)、血管紧张素受体拮抗剂(9.53%和34.18%)、β受体阻滞剂(4.32%和13.09%)及利尿剂(1.65%和6.86%)者也显著少于非0号组患者(P<0.05)。在安全性方面,2组患者及2亚组高龄患者的白细胞、血红蛋白、血小板、肝功能、肾功能、糖脂代谢、电解质水平以及抑郁焦虑评分差异均无统计学意义(P>0.05)。结论 复方利血平氨苯蝶啶片对于老年高血压患者具有明确的降压效果,可减少每日服药片数,提高患者依从性,且安全性良好。
英文摘要:
      Objective To compare the efficacy and safety of compound reserpine triamterene tablets (No.0) with other anti-hypertensive drugs for the treatment of the elderly hypertensive patients. Methods From August 2018 to December 2018, a total of 1574 elderly hypertensive patients were recruited for the study from 26 community health service centers in 10 municipalities or provinces, namely, Tianjin, Henan, Anhui, Shandong, Jiangsu, Shanxi, Sichuan, Liaoning, Beijing, and Hebei. They were divided into No.0 group who took No. 0 (matched by an age difference ≤ 5 years and gender with a ratio of 1∶1) and Non-No.0 group who did not, with 787 patients in each. Of all the patients, 186 at advanced age (≥80 years) were divided into 2 sub-groups:aged No.0 subgroup (n=102) and aged non-No.0 subgroup (n=84). The two groups were compared in clinical data and the two sub-groups were compared in terms of the lab findings and mental status scores. Statistical analysis was performed using SPSS statistics 22.0. Results No significant difference was observed in hypertension grade and blood pressure on visits between the two groups (P>0.05). The No.0 group took significantly fewer anti-hypertensive tablets daily than the non-No.0 group [(1.33±0.63) vs (1.41±0.63) pills,P<0.05]; similarly, the former group took significantly less calcium channel blocker (CCB) (16.39% vs 70.14%), angiotensin converting enzyme inhibitors (ACEI) (4.07% vs 11.82%), angiotensin receptor blocker (ARB) (9.53% vs 34.18%), beta blockers (4.32% vs 13.09%) or diuretics (1.65% vs 6.86%) than the non-No.0 group (P<0.05). In terms of safety, there was no statistically significant difference between the 2 groups and the two sub-groups at advanced age in white blood cell, hemoglobin, platelets, liver function, renal function, fasting plasma glucose, serum lipid, depression and anxiety score (P>0.05). Conclusion Compound reserpine triamterene tablets have anti-hypertensive effect in the elderly patients with good safety, reducing the number of tablets taken daily and improve patient compliance.
查看全文    下载PDF阅读器
关闭