在线办公
期刊论坛
主 管
中国人民解放军总医院
主 办
中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
梁苡菲,匡洪宇,秦文,朱文博,刘念娇,左姣,韩爽.中国北方地区2型糖尿病患者摄盐量与非酒精性脂肪性肝病的相关性[J].中华老年多器官疾病杂志,2019,18(10):765~768
中国北方地区2型糖尿病患者摄盐量与非酒精性脂肪性肝病的相关性
Correlation between salt intake and non-alcoholic fatty liver disease in type 2 diabetes mellitus patients in northern China
投稿时间:2019-05-16  
DOI:10.11915/j.issn.1671-5403.2019.10.165
中文关键词:  摄盐量;尿钠;糖尿病;非酒精性脂肪性肝病
英文关键词:salt intake; urine sodium; diabetes mellitus; non-alcoholic fatty liver disease Corresponding author:KUANG Hong-Yu, E-mail:ydyneifenmier@163.com〖FL
基金项目:
作者单位E-mail
梁苡菲 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150001  
匡洪宇 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150001 ydyneifenmier@163.com 
秦文 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150001  
朱文博 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150001  
刘念娇 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150001  
左姣 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150001  
韩爽 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150001  
摘要点击次数: 61
全文下载次数: 64
中文摘要:
      目的 探寻中国北方地区2型糖尿病患者摄盐量与非酒精性脂肪性肝病(NAFLD)之间的相关性。方法 选取2016年10月至2018年11月期间在哈尔滨医科大学附属第一医院内分泌科就诊的2型糖尿病患者978例为研究对象。依据是否合并NAFLD分为2组:NAFLD组(n=801)和非NAFLD组(n=177)。采用24h尿钠结果评估患者摄盐量。对比2组患者的体质量指数(BMI)、舒张压(DBP)、收缩压(SBP)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、胰岛素总量、糖化血红蛋白(HbA1c)、空腹C肽、空腹血糖(FBG)等临床资料。采用SPSS 17.0软件进行统计分析。对单因素分析有统计学意义的指标进行多因素logistic 回归分析,筛选出独立的危险因素。采用Spearman相关分析判断受试者摄盐量与NAFLD之间的相关性。结果 Spearman相关分析结果显示,摄盐量与NAFLD呈显著正相关(r=0.129,P<0.001)。多因素logistic回归分析结果显示,BMI(OR=5.321,95%CI 3.514~8.057)、HbA1c(OR=1.126,95%CI 1.006~1.260)、空腹C肽(OR=1.656,95%CI 1.273~2.156)、FBG(OR=1.697,95%CI 1.060~2.717)和摄盐量>10.83g/d(10.83g/d<摄盐量≤14.52g/d:OR=2.181,95%CI 1.225~3.882;摄盐量>14.52g/d:OR=2.140,95%CI 1.167~3.926)是2型糖尿病患者合并NAFLD的危险因素(P<0.05)。结论 高摄盐量(>10.83g/d)是中国北方2型糖尿病患者合并NAFLD的风险因素。
英文摘要:
      Objective To explore the correlation between salt intake and non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients in northern China. Methods A total of 978 T2DM patients hospitalized in our department from October 2016 to November 2018 were subjected in the study. They were assigned into non-NAFLD group (n=177) and NAFLD group (n=801). Their salt intake was assessed by 24-hour urinary sodium excretion.The clinical data such as body mass index (BMI), diastolic blood pressure (DBP), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), total insulin, glycosylated hemoglobin A1c (HbA1c), fasting C-peptide and fasting blood glucose (FBG) were collected and analyzed. SPSS statistics 17.0 was used to analyze the data. After the factors with statistical significance screened out by univariate analysis, the independent risk factors for NAFLD in T2DM patients were identified by multiple logistic regression analysis. Spearman correlation analysis was employed to identify the correlation between salt intake and NAFLD. Results Spearman correlation analysis showed that there was a positive correlation between salt intake and NAFLD in T2DM patients (r=0.129, P<0.001). The results of multiple logistic regression analysis indicated that BMI (OR=5.321,5%CI 3.514-8.057), HbA1c (OR=1.126,5%CI 1.006-1.260), fasting C-peptide (OR=1.656,5%CI 1.273-2.156), FBG (OR=1.697,5%CI 1.060-2.717) and salt intake >10.83g/d (10.83g/d< salt intake≤14.52g/d:OR=2.181,5%CI 1.225-3.882; salt intake >14.52g/d:OR=2.140,5%CI 1.167-3.926) were independent risk factors for NAFLD in T2DM patients (P<0.05). Conclusion High salt intake (>10.83g/d) is a risk factor for NAFLD in T2DM patients living in northern China.
查看全文    下载PDF阅读器
关闭