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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
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黄佩云,何晓璞,刘高双,孙梦雪,吴胜男,华杰.多层螺旋CT在胃神经内分泌癌与胃间质瘤中的鉴别诊断价值[J].中华老年多器官疾病杂志,2020,19(8):576~580
多层螺旋CT在胃神经内分泌癌与胃间质瘤中的鉴别诊断价值
Value of multislice spiral CT scanning in differential diagnosis of gastric neuroendocrine carcinoma and gastric stromal tumor
投稿时间:2019-10-11  
DOI:10.11915/j.issn.1671-5403.2020.08.135
中文关键词:  胃神经内分泌癌;胃间质瘤;计算机断层扫描;鉴别诊断
英文关键词:gastric neuroendocrine carcinoma; gastric stromal tumor; computer tomography; differential diagnosis This work was supported by the Joint Research Project of Southeast University-Nanjing Medical University
基金项目:东南大学-南京医科大学合作研究项目(2242018K3DN27)
作者单位E-mail
黄佩云 南京医科大学第一附属医院 老年消化内科,南京 210029 huajie@njmu.edu.cnvalue 
何晓璞 南京医科大学第一附属医院 老年消化内科,南京 210029 huajie@njmu.edu.cnvalue 
刘高双 南京医科大学第一附属医院 老年消化内科,南京 210029 huajie@njmu.edu.cnvalue 
孙梦雪 南京医科大学第一附属医院 老年消化内科,南京 210029 huajie@njmu.edu.cnvalue 
吴胜男 南京医科大学第一附属医院 老年消化内科,南京 210029 huajie@njmu.edu.cnvalue 
华杰 南京医科大学第一附属医院 消化内科,南京 210029 huajie@njmu.edu.cnvalue 
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中文摘要:
      目的 探讨胃神经内分泌癌(G-NEC)与胃间质瘤(GST)在多层螺旋CT下的影像特征。方法 回顾性分析2010年5月至2019年7月在南京医科大学第一附属医院住院治疗的G-NEC和GST患者的临床资料。依据病理结果分为2组:G-NEC组(n=21)和GST组(n=34)。对比2组的临床资料及CT特征,包括肿瘤位置、肿瘤最长径、肿瘤生长方式、肿瘤数量、肿瘤形态等。采用SPSS 22.0软件进行统计分析。2组间比较采用t检验或χ2检验。采用logistic回归分析筛选GST和G-NEC的独立鉴别因子。结果 在一般资料中,G-NEC在男性多见,而GST在女性中多见,性别可以作为GST 和G-NEC 的独立鉴别因子(OR=0.02,P=0.015)。G-NEC组(60.9±10.7)岁和GST组(60.5±13.3)岁在年龄上差异并无统计学意义(P>0.05)。通过对两组患者的CT表现分析,两组患者在肿瘤位置(P<0.001)、淋巴结转移(P=0.012)、肝转移(P=0.006)、肿瘤生长方式(P=0.014)、肿瘤形态(P<0.001)、黏膜完整性(P=0.001)和肿瘤边界(P<0.001)是否清晰上的差异均有统计学意义,随后对以上特征进行多因素分析,性别(OR=0.02,P=0.015)和肿瘤形态(OR=18.61,P=0.022)可作为GST 和G-NEC 的独立鉴别因子,其中肿瘤形态是GST 和G-NEC 最显著的鉴别因子。结论 CT对于G-NEC和GST的鉴别诊断有一定的临床意义。
英文摘要:
      Objective To investigate the imaging features of gastric neuroendocrine carcinoma (G-NEC) and gastric stromal tumor (GST) under multi-slice spiral CT scan. Methods A retrospective study was carried out on the pathologically identified G-NEC (n=21) and GST patients (n=34) who were hospitalized in our hospital from May 2010 to July 2019. The clinical data and CT features (including tumor location, tumor longest diameter, tumor growth pattern, tumor number and tumor morphology) were compared between the two groups. SPSS statistics 22.0 was used to perform the statistical analysis. Student′s t test or Chi-square test was employed for comparison between groups, and logistic regression analysis was applied to screen the independent differentiators between GST and G-NEC. Results In general data, G-NEC was more common in men, while GST was more common in women. Gender can be used as an independent distinguishing factor between GST and G-NEC (OR=0.02, P=0.015). G-NEC group (60.9±10.7 years old) and GST group (60.5±13.3 years old) had no statistical significance in age (P>0.05). Through the analysis of the CT findings of the two groups of patients, the location of the tumor (P<0.001), lymph node metastasis (P=0.012), liver metastasis (P=0.006), tumor growth pattern (P=0.014), tumor morphology ( P<0.001), mucosal integrity (P=0.001), and tumor boundary (P<0.001) were all significant differences in clarity. Subsequently, a multivariate analysis of the above characteristics was performed. Gender (OR=0.02, P=0.015) and tumor morphology (OR=18.61, P=0.022) can be used as independent distinguishing factors between GST and G-NEC, and tumor morphology was the most significant distinguishing factor between GST and G-NEC. Conclusion CT scan is of certain clinical significance for differential diagnosis between G-NEC and GST.
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