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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
刘崇霞,罗涌,林兵,王晓明.高脂血症不同治疗方式的疗效比较[J].中华老年多器官疾病杂志,2020,19(8):608~611
高脂血症不同治疗方式的疗效比较
Comparison of therapeutic effects of different hyperlipidemia treatments
投稿时间:2019-09-10  
DOI:10.11915/j.issn.1671-5403.2020.08.142
中文关键词:  高脂血症;治疗方式;药物干预;非药物干预
英文关键词:hyperlipidemia; treatment methods; drug intervention; non-drug intervention Corresponding author:WANG Xiao-Ming, E-mail:xmwang@fmmu.edu.cn〖FL
基金项目:
作者单位E-mail
刘崇霞 Department of Comprehensive Clinical Medicine, Hospital of Troop 75600, Shenzhen 518048, Guangdong Province, China xmwang@fmmu.edu.cncomparison 
罗涌 Department of Comprehensive Clinical Medicine, Hospital of Troop 75600, Shenzhen 518048, Guangdong Province, China xmwang@fmmu.edu.cncomparison 
林兵 Department of Pharmacy, No. xmwang@fmmu.edu.cncomparison 
王晓明 Department of Geriatrics, Xijing Hospital, Air Force Medical University, Xi′an 710032, China xmwang@fmmu.edu.cncomparison 
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中文摘要:
      目的 探究高脂血症不同治疗方式疗效间的差异。方法 选择2016年1月至2018年1月期间解放军75600部队医院综合临床科收治的183例高脂血症患者为研究对象,按照随机数表法分为3组:药物组、非药物组和联合组,每组61例。药物组患者接受阿托伐他汀治疗,非药物组接受健康教育、饮食结构调整和生活方式优化等非药物干预,联合组接受药物与非药物联合干预,3组患者干预时间均为12周。比较3组患者的治疗有效率,以及干预前后血甘油三酯(TG)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平,评价3组患者临床症状改善情况及治疗安全性。采用SPSS 16.0软件进行统计分析。组间比较采用F检验或χ2检验。结果 联合组治疗有效率显著高于药物组(98.36%和81.97%)和非药物组(98.36%和73.77%),差异有统计学意义(P<0.05)。治疗后联合组、药物组和非药物组TG分别为(1.41±0.35)、(1.64±0.31)和(1.59±0.29)mmol/L,TC分别为(5.06±0.19)、(5.96±0.68)和(6.11±0.51)mmol/L,LDL-C分别为(2.56±0.43)、(3.96±0.61)和(3.42±0.51)mmol/L,临床症状得分分别为(3.16±0.51)、(5.23±0.26)和(6.03±0.51),联合组均著低于药物组和非药物组(P<0.05)。联合组患者不良反应发生率显著低于药物组(4.92%和14.75%;P<0.05)。结论 药物与非药物联合干预的方式能够显著改善高脂血症患者的临床症状,提高治疗有效率,同时治疗安全性较高。
英文摘要:
      Objective To explore the difference of the therapeutic effects among different treatment methods for hyperlipidemia. Methods A total of 183 hyperlipidemia patients treated in the Hospital of Troop 75600 from January 2016 to January 2018 were enrolled as the research subjects, and were randomly divided into drug group, non-drug group and combined group, with 61 cases in each group. The patients from the drug group received atorvastatin treatment, those of the non-drug group received non-pharmaceutical interventions, such as health education, dietary adjustment and lifestyle optimization, and those of the combined group received both drug and non-drug interventions. After 12 weeks′ intervention, the treatment efficiency and blood levels of triglyceride (TG), total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) before and after the intervention were observed and evaluated for the improvement of symptoms and for therapeutic safety. SPSS statistics 16.0 was used to perform the statistical analysis. F-test or Chi-square test was employed for comparison between groups. Results The treatment efficiency was significantly higher in the combined group than in the drug group and the non-drug group (98.36% vs 81.97% and 73.77%, both P<0.05). And the combined group obtained obviously lower levels of TG [(1.41±0.35) vs (1.64±0.31) and (1.59±0.29)mmol/L], TC [(5.06±0.19) vs (5.96±0.68) and (6.11±0.51)mmol/L] and LDL-C [(2.56±0.43) vs (3.96±0.61) and (3.42±0.51)mmol/L], and decreased clinical symptom score [(3.16±0.51) vs (5.23±0.26) and (6.03±0.51)] when compared with the other 2 groups (P<0.05). The incidence of adverse reactions was significantly lower in the combined group than the drug group (4.92% vs 14.75%, P<0.05). Conclusion The combined intervention of drugs and non-drugs can significantly improve the clinical symptoms of hyperlipidemia patients, improve the efficiency of treatment, and have higher safety.
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