Xi WANG, Fan WANG. Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate[J]. Journal of Geriatric Cardiology, 2017, 14(11): 696-702. DOI: 10.11909/j.issn.1671-5411.2017.11.010
Citation: Xi WANG, Fan WANG. Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate[J]. Journal of Geriatric Cardiology, 2017, 14(11): 696-702. DOI: 10.11909/j.issn.1671-5411.2017.11.010

Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate

  • Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipo-protein (HDL). Findings from a growing number of studies further indicate that sphingosine-1-phosphate (S1P) mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protec?tion against atherosclerosis and ischemia/reperfusion injury. In this review, we summarize the most recent litera-ture investigating the effects of HDL-S1P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.
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