Xiao-Si JIANG, Li-Chao TIAN, Zi-Chao JIANG, Yu-Ting ZOU, Ping LI, Xin-Chun YANG, Xi SU, Jin-Wen TIAN, Bei SHI, Zong-Zhuang LI, Yong-Jun LI, Ren-Qiang YANG, Geng QIAN, Yun-Dai CHEN. Effects of nicorandil on myocardial infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: study design and protocol for the randomized controlled trial[J]. Journal of Geriatric Cardiology, 2020, 17(8): 519-524. DOI: 10.11909/j.issn.1671-5411.2020.08.002
Citation: Xiao-Si JIANG, Li-Chao TIAN, Zi-Chao JIANG, Yu-Ting ZOU, Ping LI, Xin-Chun YANG, Xi SU, Jin-Wen TIAN, Bei SHI, Zong-Zhuang LI, Yong-Jun LI, Ren-Qiang YANG, Geng QIAN, Yun-Dai CHEN. Effects of nicorandil on myocardial infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: study design and protocol for the randomized controlled trial[J]. Journal of Geriatric Cardiology, 2020, 17(8): 519-524. DOI: 10.11909/j.issn.1671-5411.2020.08.002

Effects of nicorandil on myocardial infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: study design and protocol for the randomized controlled trial

  • Previous studies have shown that nicorandil has a protective effect on cardiomyocytes. However, there is no study to investigate whether perioperative intravenous nicorandil can further reduce the myocardial infarct size in patients with ST-segment elevation myocardial infarction (STEMI) compared to the current standard of percutaneous coronary intervention (PCI) regimen. The CHANGE (China-Admini stration of Nicorandil Group) study is a multicenter, prospective, randomized, double-blind and parallel-controlled clinical study of STEMI patients undergoing primary PCI in China, aiming to evaluate the efficacy and safety of intravenous nicorandil in ameliorating the myocar dial infarct size in STEMI patients undergoing primary PCI and provide evidence-based support for myocardial protection strategies of STEMI patients.
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