Factors influencing the functional significance in intermediate coronary stenosis

Objective To analyze the influencing factors of the functional significance determined by fractional flow reserve (FFR) in interme-diate coronary artery stenosis. Methods The study enrolled 143 patients with 203 intermediate coronary lesions. Pressure-derived FFR of these lesions was gained at maximal hyperemia induced by intravenous adenosine infusion. An FFR Results Overall, FFR r = 0.372, P = 0.000) and the reference vessel diameters (RVD, r = 0.217, P = 0.002) were negatively correlated with percent area stenosis (AS, r = -0.251, P = 0.000) and percent diameter stenosis (DS, r = -0.210, P = 0.000). Age, MLD and the lesion location in different coronary arteries were the independent determinants of FFR Conclusions MLD can predict the functional significance of intermediate coro-nary stenosis, while age and the lesion location in different coronary arteries should be taken into account as important influencing factors of FFR values.