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Acute heart failure in the elderly: setting related differences in clinical features and management
Francesco Orso, Alessandra Pratesi, Andrea Herbst, Anna Chiara Baroncini, Francesca Bacci, Gabriele Ciuti, Andrea Berni, Camilla Tozzetti, Carlo Nozzoli, Alberto Moggi Pignone, Loredana Poggesi, Luciano Gabbani, Mauro Di Bari, Francesco Fattirolli, Massimo Milli, Andrea Ungar, Niccolò Marchionni, Samuele Baldasseroni
2021, 18(6): 407-415.   doi: 10.11909/j.issn.1671-5411.2021.06.003
Abstract(226) FullText HTML(112) PDF (49)
Epidemiology, etiology, and outcomes of in-hospital cardiac arrest in Lebanon
Ahmed Eltarras, Youssef Jalloul, Ola Assaad, Michael Bejjani, Yara Yammine, Nina Khatib, Abdallah Rebeiz, Mazen El Sayed, Marwan Refaat
2021, 18(6): 416-425.   doi: 10.11909/j.issn.1671-5411.2021.06.005
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Downregulation of miR-181a-5p alleviates oxidative stress and inflammation in coronary microembolization-induced myocardial damage by directly targeting XIAP
You ZHOU, Man-Yun LONG, Zhi-Qing CHEN, Jun-Wen HUANG, Zhen-Bai QIN, Lang LI
2021, 18(6): 426-439.   doi: 10.11909/j.issn.1671-5411.2021.06.007
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Effects of sodium-glucose cotransporter 2 inhibitors on cardiovascular outcomes in elderly patients with comorbid coronary heart disease and diabetes mellitus
Hu XU, Wen-Zhe CAO, Yong-Yi BAI, Rui-Hua CAO, Lei TIAN, Feng CAO, Li FAN
2021, 18(6): 440-448.   doi: 10.11909/j.issn.1671-5411.2021.06.001
Abstract(130) FullText HTML(64) PDF (22)
Severe bleeding following off-pump coronary artery bypass grafting: predictive factors and risk model
Yu LIU, Xing WANG, Zi-Ying CHEN, Wen-Li ZHANG, Lin GUO, Yong-Quan SUN, Hong-Zhan CUI, Ji-Qiang BU, Jian-Hui CAI
2021, 18(6): 449-461.   doi: 10.11909/j.issn.1671-5411.2021.06.006
Abstract(353) FullText HTML(175) PDF (7)
Cardiovascular risk and aging: the need for a more comprehensive understanding
Ljiljana Trtica Majnarić, Zvonimir Bosnić, Tomislav Kurevija, Thomas Wittlinger
2021, 18(6): 462-478.   doi: 10.11909/j.issn.1671-5411.2021.06.004
Abstract(151) FullText HTML(74) PDF (22)
Frailty in patients undergoing transcatheter aortic valve replacement: from risk scores to frailty-based management
Andreas Tzoumas, Damianos G. Kokkinidis, Stefanos Giannopoulos, George Giannakoulas, Leonidas Palaiodimos, Dimitrios V Avgerinos, Polydoros N Kampaktsis, Robert T. Faillace
2021, 18(6): 479-486.   doi: 10.11909/j.issn.1671-5411.2021.06.002
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A new sequential two-stent strategy for treating true distal left main trifurcation lesion
Yu-Xiang DAI, Chen-Guang LI, Jia HUANG, Ren-De XU, Shu-Fu CHANG, Hao LU, Dao-Yuan REN, Lei GE, Ju-Ying QIAN, Feng ZHANG, Jun-Bo GE
2021, 18(6): 487-491.   doi: 10.11909/j.issn.1671-5411.2021.06.008
Abstract(54) FullText HTML(27) PDF (6)
A case of applying left bundle branch pacing combined with atrioventricular node ablation to treat atrial fibrillation-induced heart failure
Lahati HA, Li-Yun HE, Lei LI, Jiang-Li HAN, Shu-Wang LIU, Yuan ZHANG, Wei XU, Wei GAO
2021, 18(6): 492-497.   doi: 10.11909/j.issn.1671-5411.2021.06.010
Abstract(76) FullText HTML(38) PDF (13)
Partial closure with a self-made fenestrated device of secundum atrial septal defect with severe pulmonary artery hypertension in adults
Tullio Tesorio, Luigi Salemme, Sebastiano Verdoliva, Marco Ferrone, Paola Tesorio, Eustaquio Maria Onorato
2021, 18(6): 498-504.   doi: 10.11909/j.issn.1671-5411.2021.06.009
Abstract(43) FullText HTML(21) PDF (7)
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Jian LIU, Surim Son, Mike Giancaterino, Miya Narushima
 doi: 10.11909/j.issn.1671-5411.2021.08.003
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 OBJECTIVE To examine whether difficulty of falling asleep (DoFA) is associated with non-high-density lipoprotein cholesterol (non-HDL-C) level among Canadian older adults. METHODS 26,954 individuals aged 45–85 years from the baseline data of the Canadian Longitudinal Study for Aging were included in this study. DoFA was categorized into five groups by answer to the question “Over the last month, how often did it take you more than 30 min to fall asleep?” Response options are “Never, < 1 time/week, 1−2 times/week, 3−5 times/week, or 6−7 times/week”. Non-HDL-C, the difference of total cholesterol and HDL-C, were categorized into five categories based on these cut-offs (< 2.6 mmol/L, 2.6−3.7 mmol/L, 3.7−4.8 mmol/L, 4.8−5.7 mmol/L, and ≥ 5.7 mmol/L). Ordinal logistic regression (logit link) continuation ratio models were used to estimate the odds of higher non-HDL-C levels for DoFA status. Adjusted means of non-HDL-C by DoFA status were estimated by general linear models. All analyses were sex separately using analytic weights to ensure generalizability. RESULTS The proportions of DoFA in five categories were 41.6%, 25.7%, 13.6%, 9.4%, 9.7% for females and 52.9%, 24.9%, 10.5%, 6.1%, 5.6% for males, respectively. After adjustment of demographical and other covariates (such as depression, comorbidity, sleeping hour, etc.) compared to those who reported never having DoFA, the ORs (95% CIs) of higher levels of non-HDL-C for those whose DoFA status in < 1 time/week, 1−2 times/week, 3−5 times/week, and 6−7 times/week were 1.12 (1.05−1.21), 1.09 (0.99−1.18), 1.20 (1.09−1.33), 1.29 (1.17−1.43) in females and 1.05 (0.98−1.13), 0.95 (0.87−1.05), 1.21 (1.08−1.37), 0.97 (0.85−1.09) in males, respectively. The adjusted means of non-HDL-C among the five DoFA status were 3.68 mmol/L, 3.73 mmol/L, 3.74 mmol/L, 3.82 mmol/L, 3.84 mmol/L for females and 3.54 mmol/L, 3.58 mmol/L, 3.51 mmol/L, 3.69 mmol/L, 3.54 mmol/L for males, respectively. CONCLUSIONS The results of this study have identified a risk association pattern between DoFA status and non-HDL-C levels in females but not in males. Further research is needed to confirm these findings.
Wei-Jun YIN, Jing JING, Ying-Qian ZHANG, Feng TIAN, Tao ZHANG, Shan-Shan ZHOU, Yun-Dai CHEN
 doi: 10.11909/j.issn.1671-5411.2021.08.001
Abstract(187) FullText HTML(92) PDF (20)
 BACKGROUND Healed plaques are frequently found in patients with acute coronary syndrome, but the prognostic value is debatable. This study investigated the clinical features of non-culprit healed plaques detected by optical coherence tomography (OCT) with the aim of predicting plaque progression of healed plaques. METHODS This study retrospectively analyzed 113 non-culprit lesions from 85 patients who underwent baseline OCT imaging and follow-up angiography from January 2015 to December 2019. Plaque progression predictors were assessed by multivariate analysis. RESULTS Among 113 non-culprit lesions, 27 healed plaques (23.9%) were identified. Patients with non-culprit healed plaques had prior antiplatelet therapy (65.0% vs. 33.8%, P = 0.019), hypertension (85.0% vs. 50.7%, P = 0.009), and dyslipidemia (70.0% vs. 41.5%, P = 0.04) which were more frequently than those without healed plaques. The thickness (r = 0.674, P < 0.001), arc (r = 0.736, P < 0.001), and volume (r = 0.541, P = 0.004) of healed plaque were correlated with minimum lumen diameter changes. At a mean follow-up of 11.5 months, the non-culprit healed plaques had a lower minimum lumen diameter (1.61 ± 0.46 mm vs. 1.91 ± 0.73 mm, P = 0.016), lower average lumen diameter (1.86 mm vs. 2.10 mm, P = 0.033), and a higher degree of diameter stenosis (41.4% ± 11.9% vs. 35.5% ± 13.1%, P = 0.031) when compared to baseline measurements. The plaque progression rate was higher in the healed plaque group (33.3% vs. 8.1%, P = 0.002), and multivariate analysis identified healed plaques [odds ratio (OR) = 8.49, 95% CI: 1.71−42.13] and lumen thrombus (OR = 10.69, 95% CI: 2.21−51.71) as predictors of subsequent lesion progression. CONCLUSIONS Healed plaques were a predictor for rapid plaque progression. The quantitative parameters of healed plaque showed a good agreement with plaque progression. Patients with healed plaque were associated with prior antiplatelet therapy and high level of low-density lipoprotein cholesterol. Bifurcation lesions might be the predilection sites of healed plaques.
Osamu Kurihara, Masamichi Takano, Yasushi Miyauchi, Kyoichi Mizuno, Wataru Shimizu
 doi: 10.11909/j.issn.1671-5411.2021.07.001
Abstract(215) FullText HTML(106) PDF (24)
Pathological studies have suggested that features of vulnerable atherosclerotic plaques likely to progress and lead to acute cardiovascular events have specific characteristics. Given the progress of intravascular coronary imaging technology, some large prospective studies have detected features of vulnerable atherosclerotic plaques using these imaging modalities. However, the rate of cardiovascular events, such as acute coronary syndrome, has been found to be considerably reduced in the limited follow-up period available in the statin era. Additionally, not all disrupted plaques lead to thrombus formation with clinical presentation. If sub-occlusive or occlusive thrombus formation does not occur, a thrombus on a disrupted plaque will organize without any symptoms, forming a “healed plaque”. Although vulnerable plaque detection using intracoronary imaging is focused on “thin-cap fibroatheroma” leading to plaque rupture, superficial plaque erosion is increasingly recognized; however, the underlying mechanism of thrombus formation on eroded plaques is not well understood. One of intravascular imaging, optical coherence tomography (OCT) has the highest image resolution and has enabled detailed characterization of the plaque in vivo. Here, we reviewed the status and limitations of intravascular imaging in terms of detecting vulnerable plaque through mainly OCT studies. We suggested that vulnerable plaque should be reconsidered in terms of eroded plaque and healed plaque and that both plaque and circulating blood should be assessed in greater detail accordingly.
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We would delightedly report that the 2020 SCI impact factor of Journal of Geriatric Cardiology(JGC,ISSN 1671-5411/ CN 11-5329/R) has increased from 2.491 to 3.327, according to the 2020 Journal Citation Reports (InCites, Clarivate Analytics), ranking 33/53 and 65/142 in the fields of Geriatrics & Gerontology and Cardiac & Cardiovascular Systems, respectively. Show more
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Li-Yuan MA, Wei-Wei CHEN, Run-Lin GAO, Li-Sheng LIU, Man-Lu ZHU, Yong-Jun WANG, Zhao-Su WU, Hui-Jun LI, Dong-Feng GU, Yue-Jin YANG, Zhe ZHENG, Sheng-Shou HU
doi: 10.11909/j.issn.1671-5411.2020.01.001
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