Xi-Fu WANG, Ming YE, Dong YAN, Hui-Min ZHANG, Ping JIA, Xue-Jun REN, Yu-Jie ZENG. Non-invasive ventilation improves hemorheology status in hypoxemic patients with acute myocardial infarction after PCI[J]. Journal of Geriatric Cardiology, 2017, 14(4): 274-279. DOI: 10.11909/j.issn.1671-5411.2017.04.007
Citation: Xi-Fu WANG, Ming YE, Dong YAN, Hui-Min ZHANG, Ping JIA, Xue-Jun REN, Yu-Jie ZENG. Non-invasive ventilation improves hemorheology status in hypoxemic patients with acute myocardial infarction after PCI[J]. Journal of Geriatric Cardiology, 2017, 14(4): 274-279. DOI: 10.11909/j.issn.1671-5411.2017.04.007

Non-invasive ventilation improves hemorheology status in hypoxemic patients with acute myocardial infarction after PCI

  • Background Hypoxemia often occurs in the emergency room in the patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI), even in those with administration of conventional high-flow oxygen inhalation. The objective of the present study was to evaluate the effectiveness of non-invasive ventilation (NIV) in improving blood oxygen content and hemorheology in patients with AMI and hypoxemia. Methods This prospective study enrolled 50 consecutive eligible patients with AMI (aged 72.3 ± 9.5 years), who had undergone PCI and been administered high-flow oxygen but still had hypoxemia. Blood was taken before NIV and at 0.5, 1, and 2 h after NIV. Blood gases, hemorheological variables including erythrocyte deformability, erythrocyte aggregation, erythrocyte osmotic fragility, membrane fluidity, and oxidative stress level were measured. Results Blood PaO2 increased to normal by 1 h after NIV. Assessed hemorheological variables had all improved and plasma malondialdehyde concentration decreased significantly after 2 h of NIV. Conclusions Our data suggest that NIV can help to improve blood oxygen content, hemorheological status, and minimize plasma lipid peroxidation injury in hypoxemic patients with AMI who have undergone PCI.
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