Please cite this article as: YE XF, ZHANG W, CHEN Y, MIAO CY, HUANG QF, SHENG CS, SHAO S, WANG D, XU SK, LEI L, ZHANG D, CHEN YL, HU LX, XIA JH, CHENG YB, WANG Y, GUO QH, LI Y, Lowres N, Freedman B, WANG JG. Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population. J Geriatr Cardiol 2022; 19(1): 52−60. DOI: 10.11909/j.issn.1671-5411.2022.01.005.
Citation: Please cite this article as: YE XF, ZHANG W, CHEN Y, MIAO CY, HUANG QF, SHENG CS, SHAO S, WANG D, XU SK, LEI L, ZHANG D, CHEN YL, HU LX, XIA JH, CHENG YB, WANG Y, GUO QH, LI Y, Lowres N, Freedman B, WANG JG. Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population. J Geriatr Cardiol 2022; 19(1): 52−60. DOI: 10.11909/j.issn.1671-5411.2022.01.005.

Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population

  •  BACKGROUND  Alcohol consumption is a known modifiable risk factor for atrial fibrillation. The association, however, might differ according to gender. We investigated gender-specific associations between alcohol consumption and incident atrial fibrillation in an elderly Chinese population.
     METHODS  Our study participants were elderly residents (≥ 65 years) recruited from five community health centers in the urban area of Shanghai (n = 6,618). Alcohol intake was classified as never drinkers and current light-to-moderate (< 40 g/day) and heavy drinkers (≥ 40 g/day). Atrial fibrillation was detected by a 30-s single-lead electrocardiography (ECG, AliveCor® Heart Monitor) and further evaluated with a regular 12-lead ECG.
     RESULTS  During a median of 2.1 years (interquartile range: 2.0−2.2) follow-up, the incidence rate of atrial fibrillation was 1.10% in all study participants. It was slightly but non-significantly higher in men (n = 2849) than women (n = 3769, 1.30% vs. 0.96%, P = 0.19) and in current drinkers (n = 793) than never drinkers (n = 5825, 1.64% vs. 1.03%, P = 0.12). In both unadjusted and adjusted analyses, there was interaction between sex and current alcohol intake in relation to the incidence of atrial fibrillation (P < 0.0001). After adjustment for confounding factors, current drinkers had a significantly higher incidence rate of atrial fibrillation than never drinkers in women (12.96% 7/54 vs. 0.78% 29/3715, adjusted odds ratio OR = 10.25, 95% confidence interval CI: 3.54−29.67, P < 0.0001), but not in men (0.81% 6/739 vs. 1.47% 31/2110, OR = 0.62, 95% CI: 0.25−1.51, P = 0.29).
     CONCLUSIONS  Our study showed a significant association between alcohol intake and the incidence of atrial fibrillation in elderly Chinese women, but not men.
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