Please cite this article as: FENG DJ, YE YQ, LI Z, ZHANG B, LIU QR, WANG WW, ZHAO ZY, ZHOU Z, ZHAO QH, YU ZK, ZHANG HT, DUAN ZY, WANG BC, LV JX, GUO S, GAO RL, XU HY, WU YJ. Development and validation of a score predicting mortality for older patients with mitral regurgitation. J Geriatr Cardiol 2023; 20(8): 577−585. DOI: 10.26599/1671-5411.2023.08.001.
Citation: Please cite this article as: FENG DJ, YE YQ, LI Z, ZHANG B, LIU QR, WANG WW, ZHAO ZY, ZHOU Z, ZHAO QH, YU ZK, ZHANG HT, DUAN ZY, WANG BC, LV JX, GUO S, GAO RL, XU HY, WU YJ. Development and validation of a score predicting mortality for older patients with mitral regurgitation. J Geriatr Cardiol 2023; 20(8): 577−585. DOI: 10.26599/1671-5411.2023.08.001.

Development and validation of a score predicting mortality for older patients with mitral regurgitation

  •  OBJECTIVE  To develop and validate a user-friendly risk score for older mitral regurgitation (MR) patients, referred to as the Elder-MR score.
     METHODS  The China Senile Valvular Heart Disease (China-DVD) Cohort Study functioned as the development cohort, while the China Valvular Heart Disease (China-VHD) Study was employed for external validation. We included patients aged 60 years and above receiving medical treatment for moderate or severe MR (2274 patients in the development cohort and 1929 patients in the validation cohort). Candidate predictors were chosen using Cox’s proportional hazards model and stepwise selection with Akaike’s information criterion.
     RESULTS  Eight predictors were identified: age ≥ 75 years, body mass index < 20 kg/m2, NYHA class III/IV, secondary MR, anemia, estimated glomerular filtration rate < 60 mL/min per 1.73 m2, albumin < 35 g/L, and left ventricular ejection fraction < 60%. The model displayed satisfactory performance in predicting one-year mortality in both the development cohort (C-statistic = 0.73, 95% CI: 0.69–0.77, Brier score = 0.06) and the validation cohort (C-statistic = 0.73, 95% CI: 0.68–0.78, Brier score = 0.06). The Elder-MR score ranges from 0 to 15 points. At a one-year follow-up, each point increase in the Elder-MR score represents a 1.27-fold risk of death (HR = 1.27, 95% CI: 1.21–1.34, P < 0.001) in the development cohort and a 1.24-fold risk of death (HR = 1.24, 95% CI: 1.17–1.30, P < 0.001) in the validation cohort. Compared to EuroSCORE II, the Elder-MR score demonstrated superior predictive accuracy for one-year mortality in the validation cohort (C-statistic = 0.71 vs. 0.70, net reclassification improvement = 0.320, P < 0.01; integrated discrimination improvement = 0.029, P < 0.01).
     CONCLUSIONS  The Elder-MR score may serve as an effective risk stratification tool to assist clinical decision-making in older MR patients.
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return