Effect of Puerarin on the myocardial perfusion and ventricular wall motion in patients with acute coronary syndrome

Objective The purpose of the present study was to investigate the effect of Puerarin (Pur) on the myocardial perfusion and ventricular wall motion in patients with acute coronary syndrome (ACS). Methods Thirty-seven patients with ACS were randomly divided into two groups: conventional group (n=17, 11 men and 6 women, with a range of age from 32 to 80 years, and with a mean age 60.9±4.9 years) and Pur group (n=20, 12 men, 8 women, with a range of age from 40 to 76 years, and with a mean age 62.7±3.5 years). Course of treatment for all patients was 10 days. Real-time myocardial contrast echocardiography (RT-MCE) was applied to two groups before and after the therapy to evaluate myocardial microcirculation and ventricular wall motion by observing the change of myocardial perfusion index (MPI) and ventricular wall motion index (VWMI). Results The level of MPI increased and VWMI decreased after 10 days of the therapy, which is significant difference between the Pur group and conventional group (P<0.05). Conclusions Puerarin can increase the level of MPI and decrease the level of VWMI in patients with ACS. Myocardial microcirculation perfusion and ventricular wall motion could be improved probably in patients with ACS treated by Puerarin.