Plasma hemoglobin concentration was related to estimated glomerular filtration rate in elderly patients with ischemic cardiomyopathy

Objectives To study the relationship between plasma hemoglobin concentration and estimated glomerular filtration rate (eGFR) in elderly patients with ischemic cardiomyopathy (ICM). Methods Clinical data of patients with coronary heart disease who were discharged from The First Affiliated Hospital, Chongqing Medical University between 2005 and 2007 were analyzed retrospectively. Echocardiography results, plasma hemoglobin and creatinine concentration were abstracted from the medical records. The study included 235 Chinese Han patients with age 60 years and older with angiography confirmed coronary heart disease, silent myocardial ischemia or angina pectoris, of whom 154 had ICM defined as left ventricular end-diastolic diameter (LVDd), male≥56 mm, female ≥51 mm (63.51±7.70 mm) measured by M-mode echocardiography. The differences in plasma hemoglobin concentration were analyzed retrospectively between patients with and without ICM, and between patients with an eGFR＜60 ml?min-1?1.73m-2 and those with an eGFR ≥60 ml?min-1?1.73m-2. Results There were no significant differences in plasma hemoglobin concentration and eGFR between ICM and non-ICM group (118.49 ± 20.52 g?L-1 vs. 115.80 ± 23.32 g?L-1 and 75.13 ± 24.21 ml?min-1?1.73m-2 vs. 79.09 ± 28.41 ml?min-1?1.73m-2, respectively, both P＞0.05). However, in both ICM and non-ICM groups, plasma hemoglobin concentration was lower in those with an eGFR<60 ml?min-1?1.73m-2 compared with compared with those with an eGFR≥60 ml?min-1?1.73m-2 group (112.29 ± 18.61 g?L-1 vs. 119.92 ± 20.74L-1, P<0.05); plasma hemoglobin concentration was related positively to eGFR. Conclusions There were no significant changes in plasma hemoglobin concentration and eGFR; however, plasma hemoglobin concentration was related to eGFR significantly positively in elderly patients with ICM due to coronary heart disease.