hs-CRP is a potential predictor of no-reflow in patients with AMI after emergency PCI

Objective The paper aims to determine whether the inflammation, a powerful risk factor that has been demonstrated for the development of coronary artery disease, plays a role in no-reflow phenomenon in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods We prospectively analyzed 656 patients with AMI after primary PCI. Based on post-PCI angiography data, patients were divided into two groups: the no-reflow group (TIMI=2, n =60) and the reflow group (TIMI=3, n =596). Results Our results showed that the inflammatory factors including leukocyte count (×109/L) (10.90±4.04 vs. 9.12±2.98 P =0.002), hs-CRP (5.04±0.71 vs. 4.70±0.75 P =0.001) and other factor platelet count (×109/L) (210.96±33.42 vs. 196.41±46.06 P =0.033) in no-reflow group are significantly higher than those in reflow group, major adverse cardiac events happened in the patients with no-reflow are higher than in reflow patients no matter in hospital or at the end of follow-up.We also found the left ventricular ejection fraction (LVEF) dramatically decreased (58.65±9.34 vs. 51.29±11.38, P<0.001) and left ventricular end-diastolic dimension (LVEDD) significantly increased (49.94±6.75 mm vs. 54.66±6.68mm, P<0.001) in no-reflow patients at the end of followup. Conclusions Our results suggest that inflammation factors function in no-reflow phenomenon, and no-reflow is a serious complication after primary PCI which predicts poor left ventricular systolic functional recovery and mortality in patients with AMI.