ISSN 1671-5411 CN 11-5329/R
Yan CHEN, Yun-Tao LI, Ming-Dong GAO, Ze-Chun ZENG, Jin-Rong ZHANG, Hong-Liang CONG, Yin LIU, Ru ZHAO, Le-Feng WANG, Xin-Cun YANG, Kang MENG. Incidence of pocket hematoma after electrophysiological device placement: dual antiplatelet therapy versus low-molecular-weight heparin regimen. J Geriatr Cardiol 2014; 11(3): 200-205. doi: 10.11909/j.issn.1671-5411.2014.03.013
Citation: Yan CHEN, Yun-Tao LI, Ming-Dong GAO, Ze-Chun ZENG, Jin-Rong ZHANG, Hong-Liang CONG, Yin LIU, Ru ZHAO, Le-Feng WANG, Xin-Cun YANG, Kang MENG. Incidence of pocket hematoma after electrophysiological device placement: dual antiplatelet therapy versus low-molecular-weight heparin regimen. J Geriatr Cardiol 2014; 11(3): 200-205. doi: 10.11909/j.issn.1671-5411.2014.03.013

Incidence of pocket hematoma after electrophysiological device placement: dual antiplatelet therapy versus low-molecular-weight heparin regimen

doi: 10.11909/j.issn.1671-5411.2014.03.013
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This study was supported by a grant from the Beijing Municipal Science & Technology Commission (No. Z11110705).

  • Received Date: 2014-05-05
  • Rev Recd Date: 2014-06-18
  • Publish Date: 2014-08-01
  • Background Given the increasing number of patients who require dual antiplatelet (DAP) therapy and electrophysiological device (EPD) placement, perioperative antiplatelet management is a current challenge. In this study, we investigated the incidence of pocket hematoma formation after EPD placement in patients undergoing DAP therapy or an alternative low-molecular-weight heparin (LMWH) regimen. Methods This clinical observational study was performed from July 2010 to July 2012. In total, 171 patients were enrolled in the analysis after meeting the inclusion criteria. These patients were divided into two groups: 86 patients were treated with DAP therapy at the time of device implantation, and the DAP therapy was discontinued for 5 to 7 days and replaced with enoxaparin before device implantation in the other 85 patients. Adenosine phosphate (ADP)-mediated platelet aggregation and arachidonic acid-induced platelet aggregation were tested preoperatively. We compared the incidence of pocket hematoma between the two groups and the association of pocket hematoma development with ADP-mediated platelet aggregation and arachidonic acid-induced platelet aggregation. Results The incidence of pocket hematoma in the patients who continued DAP was lower than that in the patients who replaced the dual antiplatelet regimen with LMWH (3.49% vs. 16.47%, respectively; X2 = 6.66, P Conclusion Continuance of DAP therapy does not increase the risk of pocket hematoma formation after EPD placement.
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