ISSN 1671-5411 CN 11-5329/R
Xin LIU, Min ZHANG, Hong-Wei SHAN, Xian-Tao SONG, Shu-Zheng LYU. Association of single nucleotide polymorphism rs2076185 in chromosome 6P24.1 with premature coronary artery diseases in Chinese Han population. J Geriatr Cardiol 2016; 13(2): 138-144. doi: 10.11909/j.issn.1671-5411.2016.02.008
Citation: Xin LIU, Min ZHANG, Hong-Wei SHAN, Xian-Tao SONG, Shu-Zheng LYU. Association of single nucleotide polymorphism rs2076185 in chromosome 6P24.1 with premature coronary artery diseases in Chinese Han population. J Geriatr Cardiol 2016; 13(2): 138-144. doi: 10.11909/j.issn.1671-5411.2016.02.008

Association of single nucleotide polymorphism rs2076185 in chromosome 6P24.1 with premature coronary artery diseases in Chinese Han population

doi: 10.11909/j.issn.1671-5411.2016.02.008
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This study is supported by National Science & Technology Pillar Program of China in the Twelfth 5-year Plan Period (2011BAI11B00). The authors declare no conflict of interest.

  • Received Date: 2015-10-10
  • Rev Recd Date: 2015-12-24
  • Publish Date: 2016-02-05
  • Objectives To study the association of single nucleotide polymorphism (SNP) rs2076185 in chromosome 6p24.1 with the premature coronary artery diseases (PCAD) in Chinese Han population. Methods A total of 1382 patients were divided into the PCAD group and the control group based on their coronary arteriography (CAG) results. Their SNP rs2076185 were analyzed by the mass-spectrometry. Their allele and genotype frequency in Hardy-Weinberg equilibrium were calculated for assessment. Logistic regression was employed to remove confounding factors and correlate SNP rs2076185 with PCAD. Results The allele and genotype frequencies of the control group were in Hardy-Weinberg equilibrium (P > 0.05). The frequencies of allele G of rs2076185 were 54.2% in the PCAD group and 49.5% in the control group. The difference was significant (P = 0.042). The genotype distribution of rs2076185 of the two groups was also significantly different. The univariate analysis showed that the rs2076185 polymorphisms were associated with the PCAD only in the additive model (OR: 0.828, 95% CI: 0.711?0.964, P = 0.014), and in the dominant model (OR: 0.753, 95% CI: 0.591?0.958, P = 0.021). After removing the confounding variables, the rs2076185 polymorphisms was associated with PCAD in the additive model (OR: 0.775, 95% CI: 0.648?0.928, P = 0.005), in the dominant model (OR: 0.698, 95% CI: 0.527?0.925, P = 0.012), and in the recessive model (OR: 0.804, 95% CI: 0.538?0.983, P = 0.038). Conclusion Allele G of rs2076185 reduces the PCAD risks in Chinese Han population, therefore it could be a coronary artery diseases protective factor in Chinese Han population.
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