Ying DU, Juan CHEN, Man-Hua CHEN, Sheng-Hua YANG, Sha LI, Yuan-Lin GUO, Cheng-Gang ZHU, Rui-Xia XU, Qian DONG, Jian-Jun LI. Relationship of lipid and lipoprotein ratios with coronary severity in patients with new on-set coronary artery disease complicated with type 2 diabetics. J Geriatr Cardiol 2016; 13(8): 685-692. doi: 10.11909/j.issn.1671-5411.2016.08.007
Citation:
Ying DU, Juan CHEN, Man-Hua CHEN, Sheng-Hua YANG, Sha LI, Yuan-Lin GUO, Cheng-Gang ZHU, Rui-Xia XU, Qian DONG, Jian-Jun LI. Relationship of lipid and lipoprotein ratios with coronary severity in patients with new on-set coronary artery disease complicated with type 2 diabetics. J Geriatr Cardiol 2016; 13(8): 685-692. doi: 10.11909/j.issn.1671-5411.2016.08.007
Ying DU, Juan CHEN, Man-Hua CHEN, Sheng-Hua YANG, Sha LI, Yuan-Lin GUO, Cheng-Gang ZHU, Rui-Xia XU, Qian DONG, Jian-Jun LI. Relationship of lipid and lipoprotein ratios with coronary severity in patients with new on-set coronary artery disease complicated with type 2 diabetics. J Geriatr Cardiol 2016; 13(8): 685-692. doi: 10.11909/j.issn.1671-5411.2016.08.007
Citation:
Ying DU, Juan CHEN, Man-Hua CHEN, Sheng-Hua YANG, Sha LI, Yuan-Lin GUO, Cheng-Gang ZHU, Rui-Xia XU, Qian DONG, Jian-Jun LI. Relationship of lipid and lipoprotein ratios with coronary severity in patients with new on-set coronary artery disease complicated with type 2 diabetics. J Geriatr Cardiol 2016; 13(8): 685-692. doi: 10.11909/j.issn.1671-5411.2016.08.007
Relationship of lipid and lipoprotein ratios with coronary severity in patients with new on-set coronary artery disease complicated with type 2 diabetics
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiology, the Central Hospital of Wuhan, Wuhan, Hubei, China
Department of Cardiology, the Central Hospital of Wuhan, Wuhan, Hubei, China
Funds:
This work was partly supported by National Natural Scientific Foundation (81070171, 81241121), Specialized Research Fund for the Doctoral Program of Higher Education of China (20111106110013), Capital Special Foundation of Clinical Application Research (Z121107001012015), Capital Health Development Fund (2011400302), and Beijing Natural Science Foundation (7131014) awarded to Dr. Jian-Jun LI.
Background Diabetes mellitus (DM) is associated with coronary artery disease (CAD) progression. Although previous studies have demonstrated the association of lipid and lipoprotein ratios with CAD, no data are currently available concerning the relationship between lipid and lipoprotein ratios and the severity of new on-set CAD in diabetics. Therefore, the aim of the present study was to investigate the usefulness of lipid and lipoprotein ratios in predicting the severity of CAD in patients with type 2 DM (T2DM). Methods A total of 380 consecutive T2DM patients with new on-set CAD were enrolled in the present study. Then, they were classified into the three groups according to Gensini score (GS) tertiles. The relationship between lipid and lipoprotein ratios currently used and the GS was investigated. Results Positive correlations of natural log-transformed GS (lnGS) with apolipoprotein B to apoA-I ratio (apoB/apoA-I), non-high-density lipoprotein cholesterol to apoA-I ratio (non-HDL-C/apoA-I), and low-density lipoprotein cholesterol to apoA-I ratio (LDL-C/apoA-I) were found (r = 0.18, 0.13, 0.12, respectively, all P P = 0.003). Area under receivers operating characteristic curve of apoB/apoA-I was 0.63 (95% CI: 0.60–0.66, P = 0.001) for predicting high GS. The optimal cutoff value of apoB/apoA-I to predict high GS was 0.72 with the sensitivity of 61.2% and the specificity of 62.1%. Conclusions Lipid and lipoprotein ratios might be useful for predicting the severity of new on-set CAD in T2DM patients, and the apoB/apoA-I appeared as the most significant predictor in this population.