ISSN 1671-5411 CN 11-5329/R

Dear Colleagues,

Journal of Geriatric Cardiology (J Geriatr Cardiol, JGC) will launch a new website and adopt ScholarOne ManuscriptsTM system to manage the submission and peer review process from November 1, 2020. To review and check the status of your manuscripts submitted before November 2020, please visit...

more

Fang-Fang WANG, Lahati HA, Hai-Yi YU, Lin MI, Jiang-Li HAN, Wei GAO. Altered serum level of cartilage oligomeric matrix protein and its association with coronary calcification in patients with coronary heart disease. J Geriatr Cardiol 2017; 14(2): 87-92. doi: 10.11909/j.issn.1671-5411.2017.02.002
Citation: Fang-Fang WANG, Lahati HA, Hai-Yi YU, Lin MI, Jiang-Li HAN, Wei GAO. Altered serum level of cartilage oligomeric matrix protein and its association with coronary calcification in patients with coronary heart disease. J Geriatr Cardiol 2017; 14(2): 87-92. doi: 10.11909/j.issn.1671-5411.2017.02.002

Altered serum level of cartilage oligomeric matrix protein and its association with coronary calcification in patients with coronary heart disease

doi: 10.11909/j.issn.1671-5411.2017.02.002
Funds:

This work was supported by a grant from the National Natural Science Foundation of China (81400262) and Backbone Fund of Peking University Third Hospital (Y72497-04). We thank Liang Ying (Department of Physiology and Pathophysiology, Basic Medical College of Peking University) for the guidance on the COMP testing. All authors have no conflict of interests regarding this paper.

  • Received Date: 2016-12-24
  • Rev Recd Date: 2016-12-24
  • Publish Date: 2017-02-28
  • Background Cartilage oligomeric matrix protein (COMP) is mainly found in the skeletal system and vascular smooth muscle cells. Recent researches showed that it had a protective function on blood vessels and could also inhibit vascular calcification. We investigated the serum COMPs in coronary heart disease (CHD) patients, and the relationship between serum COMP and the calcification of coronary artery. Methods A total of 233 consecutive chest pain patients who first underwent coronary angiography followed by multi-slice computed tomography (MSCT) within six months were recruited and divided into two groups according to the coronary angiography luminal diameter narrowing percentages: CHD group (diameter narrowing ≥ 50%, n = 194) and control group (diameter narrowing n = 39). The Gensini score, Syntax score and coronary artery calcium score (CACs) were calculated. The serum COMP level was determined using ELISA. Results The levels of COMP were significantly higher in the CHD group than in the control group 155.7 (124.5–194.5) ng/mL vs. 128.4 (113.0–159.9) ng/mL, P = 0.019. There were no correlation between COMP, Gensini score, Syntax score, severity of coronary stenosis and the number of coronary artery with stenosis > 50%. The serum COMP was correlated with age (r = 0.294, P r = 0.163, P = 0.015), HbA1c (r = 0.194, P = 0.015) and CACs (r = 0.137, P = 0.037). Stepwise linear regression analysis showed that COMP level and age were independent predictors of CACs in the CHD patients (β = 0.402, t = 2.612, P = 0.015; β = 0.472, t= 3.077, P = 0.005). Performance of COMP for predicting CHD was shown as area under curve (AUC): 0.632, 95% CI: 0.549–0.715 and upper tertile CACs was AUC: 0.602, 95% CI: 0.526–0.678 in receiver operating characteristic (ROC) curve analysis. Conclusion Calcification of coronary artery was an independent predictor of serum COMPs.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1243) PDF downloads(1117) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return