Clopidogrel induced arthritis and fever

We describe a case of a 67-year-old women who reported symptoms of fever and arthritis following initiation of therapy with clopidogrel(300mg loading dose). Physical examination and laboratory testing were normal. Incidentally, she reported experiencing the same symptoms after she received a loading dose of clopidogrel prior to a diagnostic coronary angiography in the past. The symptoms improved dramatically on discontinuation of clopidogrel.