ISSN 1671-5411 CN 11-5329/R
Shi-Wei YANG, Yu-Jie ZHOU, Ying-Xin ZHAO, Yu-Yang LIU, Xiao-Fang TIAN, Zhi-Jian WANG, De-An JIA, Hong-Ya HAN, Bin HU, Hua SHEN, Fei GAO, Lu-Ya WANG, Jie LIN, Guo-Zhong PAN, Jian ZHANG, Zhen-Feng GUO, Jie DU, Da-Yi HU. The serum anion gap is associated with disease severity and all-cause mortality in coronary artery disease. J Geriatr Cardiol 2017; 14(6): 392-400. doi: 10.11909/j.issn.1671-5411.2017.06.008
Citation: Shi-Wei YANG, Yu-Jie ZHOU, Ying-Xin ZHAO, Yu-Yang LIU, Xiao-Fang TIAN, Zhi-Jian WANG, De-An JIA, Hong-Ya HAN, Bin HU, Hua SHEN, Fei GAO, Lu-Ya WANG, Jie LIN, Guo-Zhong PAN, Jian ZHANG, Zhen-Feng GUO, Jie DU, Da-Yi HU. The serum anion gap is associated with disease severity and all-cause mortality in coronary artery disease. J Geriatr Cardiol 2017; 14(6): 392-400. doi: 10.11909/j.issn.1671-5411.2017.06.008

The serum anion gap is associated with disease severity and all-cause mortality in coronary artery disease

doi: 10.11909/j.issn.1671-5411.2017.06.008
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This work was supported by the Beijing Nova Program (No. Z121107002512053), the Beijing Health System High Level Health Technology Talent Cultivation Plan (No. 2013-3-013), the Beijing Outstanding Talent Training Program (No. 2014000021223ZK32), and the National Natural Science Foundation of China (No. 81100143) to S.W.Y., and the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (No. ZYLX201303) to Y.J.Z.

  • Received Date: 2017-05-19
  • Rev Recd Date: 2017-06-19
  • Publish Date: 2017-06-28
  • Objective To evaluate the associations between the serum anion gap (AG) with the severity and prognosis of coronary artery disease (CAD). Methods We measured serum electrolytes in 18,115 CAD patients indicated by coronary angiography. The serum AG was calculated according to the equation: AG = Na+ [(mmol/L) + K+ (mmol/L)] ? [Cl? (mmol/L) + HCO3? (mmol/L)]. Results A total of 4510 (24.9%) participants had their AG levels greater than 16 mmol/L. The serum AG was independently associated with measures of CAD severity, including more severe clinical types of CAD (P P = 0.004). Patients in the 4th quartile of serum AG (≥ 15.92 mmol/L) had a 5.171-fold increased risk of 30 days all-cause death (P P P = 0.009). Conclusion In this large population-based study, our findings reveal a high percentage of increased serum AG in CAD. Higher AG is associated with more severe clinical types of CAD and worse cardiac function. Furthermore, the increased serum AG is an independent, significant, and strong predictor of all-cause mortality. These findings support a role for the serum AG in the risk-stratification of CAD.
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