ISSN 1671-5411 CN 11-5329/R
Ru–Hui LIU, Jiang–Qi PAN, Xian–E TANG, Bing LI, Shang–Feng LIU, Wen–Lin MA. The role of immune abnormality in depression and cardiovascular disease. J Geriatr Cardiol 2017; 14(11): 703-710. doi: 10.11909/j.issn.1671-5411.2017.11.006
Citation: Ru–Hui LIU, Jiang–Qi PAN, Xian–E TANG, Bing LI, Shang–Feng LIU, Wen–Lin MA. The role of immune abnormality in depression and cardiovascular disease. J Geriatr Cardiol 2017; 14(11): 703-710. doi: 10.11909/j.issn.1671-5411.2017.11.006

The role of immune abnormality in depression and cardiovascular disease

doi: 10.11909/j.issn.1671-5411.2017.11.006
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We would like to thank Shaobo Su (Tongji Univer-sity) for the critical discussion of the conception and design. This work was supported by the Ministry of Science and Technology of China (2013CB967500) and by the Science and Technology Committee foundation of Shanghai (16411965500; 16511102802).

  • Received Date: 2017-07-20
  • Rev Recd Date: 2017-07-20
  • Publish Date: 2017-11-28
  • Depression and cardiovascular disease (CVD) are both highly prevalent disorders, and some evidence shows that there is a ‘vi-cious cycle’ linking major depression and CVD. There is also growing evidence that immune abnormalities underpin the common pathophysiology of both CVD and major depression. The abnormalities include the following: abnormal levels of inflammatory mark-ers, such as interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α) and interleukin-12 (IL-12); increased acute phase proteins, such as C-reactive protein, fibrinogen and haptoglobin; and abnormal complement factors. The findings show that ma-jor depression and CVD patients have greater immune abnormalities, which may increase depressive symptoms and cardiovascular pathological changes, and that there may be a bidirectional relationship, therefore more prospective studies are needed to draw conclu-sions.
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