Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, 100853, China
This research is supported by the National Nature Science Foundation of China (Grant No. 81500316, Fan Wang) and by the Open Project Program of the State Key Laboratory of Proteomics (Academy of Military Medical Sciences, Grant No. SKLP-O201508, Fan Wang).
Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipo-protein (HDL). Findings from a growing number of studies further indicate that sphingosine-1-phosphate (S1P) mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protec?tion against atherosclerosis and ischemia/reperfusion injury. In this review, we summarize the most recent litera-ture investigating the effects of HDL-S1P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.