ISSN 1671-5411 CN 11-5329/R
Xi WANG, Fan WANG. Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate. J Geriatr Cardiol 2017; 14(11): 696-702. doi: 10.11909/j.issn.1671-5411.2017.11.010
Citation: Xi WANG, Fan WANG. Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate. J Geriatr Cardiol 2017; 14(11): 696-702. doi: 10.11909/j.issn.1671-5411.2017.11.010

Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate

doi: 10.11909/j.issn.1671-5411.2017.11.010
Funds:

This research is supported by the National Nature Science Foundation of China (Grant No. 81500316, Fan Wang) and by the Open Project Program of the State Key Laboratory of Proteomics (Academy of Military Medical Sciences, Grant No. SKLP-O201508, Fan Wang).

  • Received Date: 2017-07-16
  • Rev Recd Date: 2017-12-31
  • Publish Date: 2017-11-28
  • Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipo-protein (HDL). Findings from a growing number of studies further indicate that sphingosine-1-phosphate (S1P) mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protec?tion against atherosclerosis and ischemia/reperfusion injury. In this review, we summarize the most recent litera-ture investigating the effects of HDL-S1P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.
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