ISSN 1671-5411 CN 11-5329/R
Shuo JIA, Yu-Jie ZHOU, Yi YU, Si-Jing WU, Yan SUN, Zhi-Jian WANG, Xiao-Li LIU, Bright Eric King, Ying-Xin ZHAO, Dong-Mei SHI, Yu-Yang LIU, Zhi-Ming ZHOU. Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome. J Geriatr Cardiol 2018; 15(2): 146-152. doi: 10.11909/j.issn.1671-5411.2018.02.005
Citation: Shuo JIA, Yu-Jie ZHOU, Yi YU, Si-Jing WU, Yan SUN, Zhi-Jian WANG, Xiao-Li LIU, Bright Eric King, Ying-Xin ZHAO, Dong-Mei SHI, Yu-Yang LIU, Zhi-Ming ZHOU. Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome. J Geriatr Cardiol 2018; 15(2): 146-152. doi: 10.11909/j.issn.1671-5411.2018.02.005

Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome

doi: 10.11909/j.issn.1671-5411.2018.02.005
Funds:

This work were supported by the grant from National Key Research and Development Program of China (2017 YFC0908800), the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (code: ZYLX201303), the National Key Clini?cal speciality Construction Project (2013–2014), and the “Beijing Municipal Administration of Hospitals” Ascent Plan (code: DFL20150601)

  • Received Date: 2017-11-07
  • Rev Recd Date: 2018-02-02
  • Publish Date: 2018-02-28
  • Background Obstructive sleep apnea (OSA) is a common disease in patients with acute coronary syndrome (ACS) and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography. We divided the patients into two groups: moderate to severe OSA group [apnea-hypopnea index (AHI) > 15 events/h] and control group (AHI ≤ 15 events/h). They were followed up for up 32 months. Then, we compared the ACS severity and long-term major adverse cardiovascular events (MACE) in patients with different severity of OSA. Results Five hundred and twenty nine patients were included in the final analysis, with 76% of them being men and an average age of 59 ± 10 years. The overall mean AHI is 29 ± 19 events/h, 70.5% of them (373/529) being with moderate to severe OSA and 29.5% (156/529) assign into control group. Compared with controls, patients with moderate or severe OSA exhibited a higher prevalence of hypertension as well as higher body mass index, SYNTAX score, Epworth score and length of hospitalization. With a median follow-up duration of 30 months, accumulative rate of MACE was also higher in patients with moderate or severe OSA than that in the control group (8.6% vs. 3.2%, P = 0.028). After adjusting for baseline confounders by cox regression model, moderate to severe OSA was an independent risk factor of long-term MACE (P = 0.047, HR = 1.618, 95% CI: 1.069–3.869). Conclusions The results of this study demonstrate that moderate or severe OSA is correlated with disease severity and associated with worse long-term prognosis in ACS patients. The results raising the possibility that early diagnose and interventions of OSA could improve long-term outcomes in ACS patients.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1110) PDF downloads(699) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return