ISSN 1671-5411 CN 11-5329/R
Julio Perez-Downes, Carlos Palacio, Saif Ibrahim, Patrisha Shelley, Alan Miller, Pramod Reddy. Prognostic utility of NT-proBNP greater than 70,000 pg/mL in patients with end stage renal disease. J Geriatr Cardiol 2018; 15(7): 476-478. doi: 10.11909/j.issn.1671-5411.2018.07.002
Citation: Julio Perez-Downes, Carlos Palacio, Saif Ibrahim, Patrisha Shelley, Alan Miller, Pramod Reddy. Prognostic utility of NT-proBNP greater than 70,000 pg/mL in patients with end stage renal disease. J Geriatr Cardiol 2018; 15(7): 476-478. doi: 10.11909/j.issn.1671-5411.2018.07.002

Prognostic utility of NT-proBNP greater than 70,000 pg/mL in patients with end stage renal disease

doi: 10.11909/j.issn.1671-5411.2018.07.002
  • Received Date: 2018-01-22
  • Rev Recd Date: 2018-01-22
  • Publish Date: 2018-07-28
  • Background Elevated NT-pro-BNP level has been identified as an independent predictor of mortality in heart failure and end stage renal disease. Previous studies diverge on NT-proBNP values predictive of mortality. The highest recorded NT-proBNP value in our institution is >70,000 pg/ml. No study to date has determined the association between a uniformly elevated NT-proBNP level and mortality. Methods Retrospective data from January 1, 2012 through January 30, 2016 was collected from patients with NT-proBNP>70,000 pg/ml. Mortality rate was determined via chart review or through the social security death index. Additional variables were gathered via systematic chart review. Results All-cause mortality was 45.39%, with a mean survival time of 204.1 days. There was a statistically significant difference in mortality (p=0.0089) and survival (p=0.0043) among patients with an ejection fraction 70,000 pg/ml, mortality rate is nearly 50%. Systolic heart failure with a left ventricular ejection fraction of <25% is a strong predictor of mortality in these patients.
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