ISSN 1671-5411 CN 11-5329/R
Matteo Briguglio, Luigi Gianturco, Daniele Stella, Chiara Colombo, Marika Bonadies, Oscar Sala, Mauro Anselmi, Giuseppe Banfi, Maurizio Turiel. Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery. J Geriatr Cardiol 2018; 15(8): 519-522. doi: 10.11909/j.issn.1671-5411.2018.08.005
Citation: Matteo Briguglio, Luigi Gianturco, Daniele Stella, Chiara Colombo, Marika Bonadies, Oscar Sala, Mauro Anselmi, Giuseppe Banfi, Maurizio Turiel. Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery. J Geriatr Cardiol 2018; 15(8): 519-522. doi: 10.11909/j.issn.1671-5411.2018.08.005

Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery

doi: 10.11909/j.issn.1671-5411.2018.08.005
Funds:

This study was part of the project “Ricerca Corrente del Ministero Della Salute”.

  • Received Date: 2018-05-23
  • Rev Recd Date: 2018-05-23
  • Publish Date: 2018-08-28
  • Background Cardiovascular diseases and insufficient levels of vitamin D are risk factors for adverse surgical outcomes, and they are both commonly present among older adults undergoing orthopaedic surgery. Giving the cardiovascular effects of vitamin D, pre-operative diagnosis of hypovitaminosis D would be a valuable step for the implementation of supplementation protocols. We investigated if the normalization of serum 25 [OH] D could ameliorate cardiac performance of older adults suffering from cardiovascular diseases. Methods We enrolled 47 older adults scheduled for major orthopaedic surgery and suffering from hypovitaminosis D. Patients underwent 6-months calcifediol supplementation with a starting dose at first post-operative day of 50 μg/die in liquid preparation. Down-titration to 20 μg/die at 3-months assessment was planned. Cardiac performance was evaluated by measuring left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) during pre-operative assessments and at 1-month, 3-months, 6-months follow-ups. Results Six months of calcifediol supplementation were associated with a significant improvement of both LVEF (+ 3.94%; 95% CI: -4.0789 - -0.8232; P P Conclusions Calcifediol supplementation normalized serum 25 [OH] D concentration after 1-month treatment. GLS offered better insights into myocardial contractile amelioration than LVEF, thus being useful for detecting earlier subclinical changes that may anticipate hemodynamic modifications.
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