ISSN 1671-5411 CN 11-5329/R
Ji-Xuan LIU, Yan-Ping LI, Bo-Han LIU, Xiao-Jing ZHAO, Ze-Yu ZHANG, Jin-Da WANG, Qian JIA, Chun-Lei LIU, Xiao-Jian GAO, Zhen-Guo XU, Hua-Wei ZHANG, Lin-Nan SONG, Zhi-Jun SUN, Kun-Lun HE. Repeated measurement of growth-differentiation factor-15 in Chinese Han patients with post-myocardial infarction chronic heart failure. J Geriatr Cardiol 2018; 15(10): 618-627. doi: 10.11909/j.issn.1671-5411.2018.10.002
Citation: Ji-Xuan LIU, Yan-Ping LI, Bo-Han LIU, Xiao-Jing ZHAO, Ze-Yu ZHANG, Jin-Da WANG, Qian JIA, Chun-Lei LIU, Xiao-Jian GAO, Zhen-Guo XU, Hua-Wei ZHANG, Lin-Nan SONG, Zhi-Jun SUN, Kun-Lun HE. Repeated measurement of growth-differentiation factor-15 in Chinese Han patients with post-myocardial infarction chronic heart failure. J Geriatr Cardiol 2018; 15(10): 618-627. doi: 10.11909/j.issn.1671-5411.2018.10.002

Repeated measurement of growth-differentiation factor-15 in Chinese Han patients with post-myocardial infarction chronic heart failure

doi: 10.11909/j.issn.1671-5411.2018.10.002
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This study was supported by the Chinese PLA General Hospital Medical Large Data Project (No. 2016MBD-002), the Chinese PLA General Hospital Fund (No. 2017TM-001) and the Biological Medicine and Life Science Cultivation Foundation of Beijing Municipal Science and Technology Commission (No. Z151100003915075).

  • Received Date: 2018-04-27
  • Rev Recd Date: 2018-08-15
  • Publish Date: 2018-10-28
  • Background Growth-differentiation factor-15 (GDF-15) is a promising prognostic biomarker in patients with chronic heart failure (CHF). Comparatively little is known about the value of repeated measurement of GDF-15 with CHF in Chinese Han population. This study sought to identify the clinical value of repeated measurement of GDF-15 in Chinese Han patients with post-myocardial infarction CHF. Methods In total, 232 consecutive Chinese Han patients with post-myocardial infarction CHF were enrolled prospectively from January 2014 to June 2016.The plasma concentration of GDF-15 was determined on admission and over 12 months. Patients were followed up for all-cause death and a composite outcome of major adverse cardiac events (MACE) included all-cause death, myocardial infarction and first heart failure (HF) re-hospitalization. Association with other clinical variables and adverse outcomes of repeated measurement of GDF-15 was explored. Results The median baseline GDF-15 level was 2025 ng/L. Baseline GDF-15 was moderately associated with baseline N-terminal pro-B type natriuretic peptide (NT-proBNP) (coefficient 0.561, P P = 0.037) and MACE (adjusted hazard ratio 2.243 per 1 Ln U, 95% CI: 1.181–1.775; P P = 0.015). In the joint model, GDF-15 was also shown to be a risk factor for all-cause death (HR = 2.749, 95% CI: 1.667–3.831; P P Conclusions Repeated measurements of GDF-15 have promising prognostic value of the risk of all-cause death in Chinese Han patients with CHF post-myocardial infarction. GDF-15 may influence the post-myocardial infarction CHF through the path physiological pathway of myocardial remodeling.
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