ISSN 1671-5411 CN 11-5329/R
Jing BAI, Yan YUE, Hong-Qi FENG, Shu-Xin HAO, Liang PENG, Ming ZHANG, Shaheena Nazneen, Li-Feng LIU, Zhe TANG, Xiao-Lin YU, Yu-Tao XIE, Fu-Xiang SHAN, Ming-Zhi SHEN, Jiang-Tao WANG, Xue-Hua WAN, Yun-Dai CHEN, Yu WANG. Impact of main vessel calcification on procedural and clinical outcomes of bifurcation lesion undergoing provisional single-stenting intervention: a multicenter, prospective, observational study. J Geriatr Cardiol 2019; 16(2): 156-163. doi: 10.11909/j.issn.1671-5411.2019.02.012
Citation: Jing BAI, Yan YUE, Hong-Qi FENG, Shu-Xin HAO, Liang PENG, Ming ZHANG, Shaheena Nazneen, Li-Feng LIU, Zhe TANG, Xiao-Lin YU, Yu-Tao XIE, Fu-Xiang SHAN, Ming-Zhi SHEN, Jiang-Tao WANG, Xue-Hua WAN, Yun-Dai CHEN, Yu WANG. Impact of main vessel calcification on procedural and clinical outcomes of bifurcation lesion undergoing provisional single-stenting intervention: a multicenter, prospective, observational study. J Geriatr Cardiol 2019; 16(2): 156-163. doi: 10.11909/j.issn.1671-5411.2019.02.012

Impact of main vessel calcification on procedural and clinical outcomes of bifurcation lesion undergoing provisional single-stenting intervention: a multicenter, prospective, observational study

doi: 10.11909/j.issn.1671-5411.2019.02.012
Funds:

This study was supported by the National Natural Sci-ence Foundation of China (No. 81670218-Mechanism study of CKIP?1 Regulating programmed necrosis induced by Myocardial Reperfusion Injury).

  • Received Date: 2018-11-23
  • Rev Recd Date: 2018-12-16
  • Publish Date: 2019-02-28
  • Background Few data on the combined effects of bifurcation and calcification on coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) are available. This study evaluated the impact of main vessel (MV) calcification on the procedural and long-term outcomes in patients with CAD who underwent provisional single stent PCI. Methods This is a multicenter, prospective, observational study. Patients with bifurcation lesions were enrolled at 10 PCI centers in China from January 2015 to December 2017. Intravascular ultrasound or optical coherence tomography was performed in all patients to evaluate the MV calcification. Patients were treated with provisional single stent strategy using drug eluting stents and followed-up at 1 month, 6 months and 12 months after discharge by telephone contact or outpatient visit. Repeated coronary imaging was performed within one year. We compared the procedural success rates in MV and in side-branch (SB), and target lesion failure (TLF), defined as a composite of cardiac death, non-fatal myocardial infarction, definite or possible stent thrombosis and target lesion revascularization between patients with and without MV calcification. Results A total of 185 subjects were enrolled according to the inclusion and exclusion criteria of this study. MV calcification was detected in 119 (64.3%, calcification group) and not found in 66 (35.7%, non-calcification group) patients. The angiographic success rate of MV was 95.8% in the calcification group and 97.0% in the non-calcification group (P = 0.91); the angiographic success rate of SB was 32.8% in the calcification group and 53.0% in the non-calcification group (P P = 0.31). Multivariate regression analysis showed the same result (HR = 1.23, 95% CI: 0.76-1.52, P = 0.47). Calcification on group had higher recurrent angina than non-calcification group (13.51% vs. 17.65%, P Conclusions In patients with coronary bifurcation lesion treated with provisional one stent approach, calcification of MV is associated with lower SB procedural success rate, it could increase recurrence of angina; however, it was not associated with an increased risk of TLF.
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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