ISSN 1671-5411 CN 11-5329/R

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Chen-Xi JIANG, Jian-Gang WANG, Rui-Dong QI, Wei WANG, Li-Jian GAO, Jing-Hua ZHAO, Chun-Xiao ZHANG, Meng-Chen ZHOU, Xin TU, Mei-Sheng SHANG, Yan YAO. Long-term outcome of patients with atrial myxoma after surgical intervention: analysis of 403 cases. J Geriatr Cardiol 2019; 16(4): 338-343. doi: 10.11909/j.issn.1671-5411.2019.04.003
Citation: Chen-Xi JIANG, Jian-Gang WANG, Rui-Dong QI, Wei WANG, Li-Jian GAO, Jing-Hua ZHAO, Chun-Xiao ZHANG, Meng-Chen ZHOU, Xin TU, Mei-Sheng SHANG, Yan YAO. Long-term outcome of patients with atrial myxoma after surgical intervention: analysis of 403 cases. J Geriatr Cardiol 2019; 16(4): 338-343. doi: 10.11909/j.issn.1671-5411.2019.04.003

Long-term outcome of patients with atrial myxoma after surgical intervention: analysis of 403 cases

doi: 10.11909/j.issn.1671-5411.2019.04.003
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This study was supported by grants from the National Natural Science Foundation of China (No.81670294 & No.81200141 & No.81470430 & No.81770320 & No.81570291) and the Beijing Novel Program (No.2011081 & Z131103000413116).

  • Received Date: 2018-10-05
  • Rev Recd Date: 2019-04-02
  • Publish Date: 2019-04-28
  • Objective To assess long-term survival and late cardiovascular events in patients with atrial myxoma after surgical intervention. Methods Retrospective analysis of 403 patients undergoing resection of atrial myxoma from January 2002 to December 2016 was con-ducted with a median follow-up period of 4.5 (range: 0.5-15) years. Results The cross-clamp time and cardiopulmonary bypass times were 41.1 ± 21.4 and 65.2 ± 27.3 min, respectively. A diagnosis of myxoma was histopathologically confirmed in all cases. The early in-hospital mortality rate was 0.7% (n = 3). During the follow-up period, tumor recurrence occurred in six patients and cerebral infarction in nine. There were 48 (11.9%) patients with late onset atrial fibrillation (AF). By multivariate analysis, age (HR = 1.05, 95% CI: 1.02–1.09, P P = 0.012), and mitral valve surgery (HR = 1.17, 95% CI: 1.05–1.29, P = 0.027) were independent predictors of late onset AF. Twenty-one (5.2%) patients died during the follow-up period. Advanced age (HR = 1.07, 95% CI: 1.04–1.10, P = 0.003) and multiple surgical procedures (HR = 1.18, 95% CI: 1.06–1.29, P = 0.012) were significantly associated with overall mortality. Conclusions Atrial myxoma can be resected with good long-term survival. Late onset AF is common after surgery in patients with atrial myxoma. Advanced age, left atrial diameter, and mitral valve surgery were independent predictors of outcomes.
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