ISSN 1671-5411 CN 11-5329/R
Martijn S. van Mourik, Nathalie van der Velde, Giulio Mannarino, Marie-Pierre Thibodeau, Jean-Bernard Masson, Gennaro Santoro, Jan Baan, Sofie Jansen, Jana Kurucova, Martin Thoenes, Cornelia Deutsch, Andreas W. Schoenenberger, Andrea Ungar, Peter Bramlage, M Marije Vis. Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry. J Geriatr Cardiol 2019; 16(6): 468-477. doi: 10.11909/j.issn.1671-5411.2019.06.001
Citation: Martijn S. van Mourik, Nathalie van der Velde, Giulio Mannarino, Marie-Pierre Thibodeau, Jean-Bernard Masson, Gennaro Santoro, Jan Baan, Sofie Jansen, Jana Kurucova, Martin Thoenes, Cornelia Deutsch, Andreas W. Schoenenberger, Andrea Ungar, Peter Bramlage, M Marije Vis. Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry. J Geriatr Cardiol 2019; 16(6): 468-477. doi: 10.11909/j.issn.1671-5411.2019.06.001

Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry

doi: 10.11909/j.issn.1671-5411.2019.06.001
Funds:

A research grant was provided by Edwards Lifesciences (Nyon, Switzerland) to the Sponsor IPPMed (Cloppenburg, Germany). Peter Bramlage is the representative of IPP-Med, Cloppenburg, Germany. Jan Baan received research funding from Edwards Lifesciences as did Andrea Ungar.

  • Received Date: 2019-05-03
  • Rev Recd Date: 2019-05-03
  • Publish Date: 2019-06-28
  • Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan-Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (651) PDF downloads(372) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return