ISSN 1671-5411 CN 11-5329/R
Cai-Xia GUO, Zhi-Yuan LI, Jin-Bang NIU, Shuan-Cheng FAN, Si-Yu YAN, Pei-Pei LU, Yan-Ni SU, Li-Hong MA. Qishen capsule safely boosts cardiac function and angiogenesis via the MEK/ERK pathway in a rat myocardial infarction model. J Geriatr Cardiol 2019; 16(10): 764-774. doi: 10.11909/j.issn.1671-5411.2019.10.008
Citation: Cai-Xia GUO, Zhi-Yuan LI, Jin-Bang NIU, Shuan-Cheng FAN, Si-Yu YAN, Pei-Pei LU, Yan-Ni SU, Li-Hong MA. Qishen capsule safely boosts cardiac function and angiogenesis via the MEK/ERK pathway in a rat myocardial infarction model. J Geriatr Cardiol 2019; 16(10): 764-774. doi: 10.11909/j.issn.1671-5411.2019.10.008

Qishen capsule safely boosts cardiac function and angiogenesis via the MEK/ERK pathway in a rat myocardial infarction model

doi: 10.11909/j.issn.1671-5411.2019.10.008
Funds:

This study was supported by the Fuwai Hospital (No.2013-ZX009).

  • Received Date: 2019-08-10
  • Rev Recd Date: 2019-08-10
  • Publish Date: 2019-10-28
  • Background Qishen (QS) capsules, a Traditional Chinese Medicine, has been widely used to treat coronary heart disease in China. However, evidence of its effectiveness remains unclear. Methods To explore whether QS has cardioprotective efficacy and/or promotes angiogenesis after myocardial infarction (MI), we performed experiments in a preclinical rat MI model. One month after left anterior descending coronary artery ligation, the rats received either QS solution (0.4 g/kg/day) or the same volume of saline by intragastric injection for four weeks. Results Echocardiographic and hemodynamic analyses demonstrated relatively preserved cardiac function in MI rats administered QS. Indeed, QS treatment was associated with reduced infarct scar size and heart weight index, and these beneficial effects were responsible for enhancing angiogenesis. Mechanistically, QS treatment increased phosphorylation of protein kinase B (Akt) and downregulated phosphorylation of mitogen-activated protein kinase/extracellular-regulated kinase (MEK/ERK). Conclusions QS therapy can improve the cardiac function of rats after MI by an underlying mechanism involving increased angiogenesis, at least partially via activation of the Akt signaling pathway and inhibition of MEK/ERK phosphorylation.
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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