ISSN 1671-5411 CN 11-5329/R
Dong-Yan HOU, Lin XU, Zhi-Yong ZHANG, Xiao-Rong XU, Xin WANG, Juan ZHANG, Jia-Mei LIU, Hua WANG, Jin CHEN, Lin ZHANG. Clinical value of detecting autoantibodies against β1-, β2-, and α1-adrenergic receptors in carvedilol treatment of patients with heart failure. J Geriatr Cardiol 2020; 17(6): 305-312. doi: 10.11909/j.issn.1671-5411.2020.06.002
Citation: Dong-Yan HOU, Lin XU, Zhi-Yong ZHANG, Xiao-Rong XU, Xin WANG, Juan ZHANG, Jia-Mei LIU, Hua WANG, Jin CHEN, Lin ZHANG. Clinical value of detecting autoantibodies against β1-, β2-, and α1-adrenergic receptors in carvedilol treatment of patients with heart failure. J Geriatr Cardiol 2020; 17(6): 305-312. doi: 10.11909/j.issn.1671-5411.2020.06.002

Clinical value of detecting autoantibodies against β1-, β2-, and α1-adrenergic receptors in carvedilol treatment of patients with heart failure

doi: 10.11909/j.issn.1671-5411.2020.06.002
Funds:

This study was supported by the Beijing Natural Science Foundation (No.7174306).

  • Received Date: 2019-11-13
  • Rev Recd Date: 2020-03-05
  • Publish Date: 2020-06-28
  • Objective To determine the possible association of anti-β1-adrenergic receptors (anti-β1-AR), anti-β2-AR and anti-α1-AR with carvedilol treatment in patients with heart failure (HF). Methods A total of 267 HF patients were prospectively enrolled. Blood samples were measured by an enzyme-linked immunosorbent assay. All of the patients received carvedilol for their HF. Each patient was followed up for six months and their cardiac function was measured. Results The final analysis encompassed 137 patients comprising 65 patients with three autoantibodies (positive group) and 72 patients without all three autoantibodies but with one or two autoantibodies (negative group). The frequency and geometric mean titer of anti-β1-AR, anti-β2-AR, and anti-α1-AR were significantly lower in the group without all three autoantibodies after six months of carvedilol treatment (all P P P Conclusions Carvedilol treatment significantly decreases frequency and geometric mean titer in patients with all three autoantibodies, even up to complete ablation, and significantly improved cardiac function and remodelling. The effect of carvedilol is probably correlated to the presence of all three autoantibodies.
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