ISSN 1671-5411 CN 11-5329/R
Volume 17 Issue 7
Aug.  2020
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Article Contents
Jia-Liu WEI, Xin-Yan WANG, Fang-Chao LIU, Ji-Chun CHEN, Jie CAO, Jian-Xin LI, Dong-Sheng HU, Chong SHEN, Fang-Hong LU, Ying-Xin ZHAO, Jian-Feng HUANG, Xiang-Feng LU. Associations of soybean products intake with blood pressure changes and hypertension incidence: the China-PAR project. J Geriatr Cardiol 2020; 17(7): 384-392. doi: 10.11909/j.issn.1671-5411.2020.07.005
Citation: Jia-Liu WEI, Xin-Yan WANG, Fang-Chao LIU, Ji-Chun CHEN, Jie CAO, Jian-Xin LI, Dong-Sheng HU, Chong SHEN, Fang-Hong LU, Ying-Xin ZHAO, Jian-Feng HUANG, Xiang-Feng LU. Associations of soybean products intake with blood pressure changes and hypertension incidence: the China-PAR project. J Geriatr Cardiol 2020; 17(7): 384-392. doi: 10.11909/j.issn.1671-5411.2020.07.005

Associations of soybean products intake with blood pressure changes and hypertension incidence: the China-PAR project

doi: 10.11909/j.issn.1671-5411.2020.07.005
*The authors contributed equally to this work.
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  • Corresponding author: Xiang-Feng LU, PhD, Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, China. E-mail:
  • Received Date: 2020-03-18
  • Accepted Date: 2020-07-11
  • Rev Recd Date: 2020-06-28
  • Available Online: 2020-07-28
  • Publish Date: 2020-07-28
  •  Background The relationships between dietary intake of soybean products and incident hypertension were still uncertain. This study aimed to illustrate the associations between intake of soybean products with risks of incident hypertension and longitudinal changes of blood pressure in a prospective cohort study. Methods We included 67, 499 general Chinese adults from the Project of Prediction for Atherosclerosis Cardiovascular Disease Risk in China (China-PAR). Information about soybean products consumption was collected by standardized questionnaires, and study participants were categorized into the ideal (≥ 125 g/day) or non-ideal (< 125 g/day) group. Hazard ratios (HRs) and corresponding 95% confidence intervals (95% CIs) for incident hypertension were calculated using Cox proportional hazard models. Among participants with repeated measures of blood pressure, generalized linear models were used to examine the relationships between soybean products consumption and blood pressure changes. Results During a median follow-up of 7.4 years, compared with participants who consumed < 125 g of soybean products per day, multivariable adjusted HR for those in the ideal group was 0.73 (0.67-0.80). This inverse association remained robust across most subgroups while significant interactions were tested between soybean products intake and age, sex, urbanization and geographic region (P values for interaction < 0.05). The mean systolic and diastolic blood pressure levels were 1.05 (0.71-1.39) mmHg and 0.44 (0.22-0.66) mmHg lower among participants in the ideal group than those in the non-ideal group. Conclusions Our study showed that intake of soybean products might reduce the long-term blood pressure levels and hypertension incidence among Chinese population, which has important public health implications for primary prevention of hypertension.
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