ISSN 1671-5411 CN 11-5329/R
Volume 17 Issue 9
Oct.  2020
Turn off MathJax
Article Contents
Zhi-Nan LU, Mario Evora, Edmundo Lao, Man Ieng Pun, Weng Hong Pun, Monica Pon, Kong Chu, Pui I Ieong, Toi-Meng Mok, Yong-Jian WU. The aging burden of hospitalization for heart failure in Chinese populations: evidence from the Macao Heart Failure Study. J Geriatr Cardiol 2020; 17(9): 533-543. doi: 10.11909/j.issn.1671-5411.2020.09.008
Citation: Zhi-Nan LU, Mario Evora, Edmundo Lao, Man Ieng Pun, Weng Hong Pun, Monica Pon, Kong Chu, Pui I Ieong, Toi-Meng Mok, Yong-Jian WU. The aging burden of hospitalization for heart failure in Chinese populations: evidence from the Macao Heart Failure Study. J Geriatr Cardiol 2020; 17(9): 533-543. doi: 10.11909/j.issn.1671-5411.2020.09.008

The aging burden of hospitalization for heart failure in Chinese populations: evidence from the Macao Heart Failure Study

doi: 10.11909/j.issn.1671-5411.2020.09.008
More Information
  • Corresponding author: Toi-Meng Mok, Cardiology Department, Centro Hospitalar Conde de São Januário, Macao, SAR, China.E-mails:tmmok@hotmail.com; Yong-Jian WU, MD, PhD, Coronary Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. E-mails: wuyongjian@fuwai.com
  • Received Date: 2020-08-14
  • Accepted Date: 2020-09-25
  • Rev Recd Date: 2020-09-18
  • Available Online: 2020-09-28
  • Publish Date: 2020-10-17
  •  Objective To assess the aging burden of hospitalization for heart failure in Chinese populations in Macao. Methods The Macao Heart Failure Study consists of patients hospitalized with a diagnosis of acute heart failure (AHF) at Centro Hospitalar Conde de São Januário (the only public hospital that provides medical care for the approximately 600, 000 residents of Macao) from January 2014 to December 2016. First, we investigated the relationship between socioeconomic development and epidemiological characteristics of HF in Macao. Then we assessed the patientso clinical features and outcomes according to the age groups. Results A total of 967 patients were included in the final analysis. The median age at admission was 82 years old. The advanced age at the admission of HF in Macao was significantly associated with a high-income level and the aging population structure. Marked heterogeneity existed in the epidemiological characteristics, clinical features, utilization of evidence-based therapies, short- and long-term outcomes, and prognostic utility of clinical variables among the different age groups. Conclusion Rapid economic development and significantly aging populations have produced a profound impact on the epidemiological characteristics of HF in Chinese populations. Acute decompensated heart failure (ADHF) is predominantly a disease of the elderly in Macao, and a significant heterogeneity exists in the clinical features, managements, and outcomes among different age groups. Age-based risk stratification models and multidisciplinary HF teams are urgently needed to improve the management and outcomes of hospitalized heart failure (HHF) patients.
  • loading
  • [1]
    Writing Committee M, Acc/Aha Task Force M. 2016 ACC/ AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. J Card Fail 2016; 22: 659–669. doi: 10.1016/j.cardfail.2016.07.001
    [2]
    van der Meer P, Gaggin HK, Dec GW. ACC/AHA versus ESC Guidelines on Heart Failure: JACC Guideline Comparison. J Am Coll Cardiol 2019; 73: 2756–2768. https://www.sciencedirect.com/science/article/pii/S0735109719346996
    [3]
    Driver JA, Djousse L, Logroscino G, et al. Incidence of cardiovascular disease and cancer in advanced age: prospective cohort study. BMJ 2008; 337: a2467. doi: 10.1136/bmj.a2467
    [4]
    Bleumink GS, Knetsch AM, Sturkenboom MC, et al. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J 2004; 25: 1614–1619. doi: 10.1016/j.ehj.2004.06.038
    [5]
    Teixeira A, Parenica J, Park JJ, et al. Clinical presentation and outcome by age categories in acute heart failure: results from an international observational cohort. Eur J Heart Fail 2015; 17: 1114–1123. doi: 10.1002/ejhf.330
    [6]
    Adams KF, Jr., Fonarow GC, Emerman CL, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100, 000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 2005; 149: 209–216. doi: 10.1016/j.ahj.2004.08.005
    [7]
    Gheorghiade M, Abraham WT, Albert NM, et al. Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA 2006; 296: 2217–2226. doi: 10.1001/jama.296.18.2217
    [8]
    Nieminen MS, Brutsaert D, Dickstein K, et al. EuroHeart Failure Survey Ⅱ (EHFS Ⅱ): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J 2006; 27: 2725–2736. doi: 10.1093/eurheartj/ehl193
    [9]
    Maggioni AP, Dahlstrom U, Filippatos G, et al. EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail 2010; 12: 1076–1084. doi: 10.1093/eurjhf/hfq154
    [10]
    Oliva F, Mortara A, Cacciatore G, et al. Acute heart failure patient profiles, management and in-hospital outcome: results of the Italian Registry on Heart Failure Outcome. Eur J Heart Fail 2012; 14: 1208–1217. doi: 10.1093/eurjhf/hfs117
    [11]
    Zannad F, Mebazaa A, Juilliere Y, et al. Clinical profile, contemporary management and one-year mortality in patients with severe acute heart failure syndromes: The EFICA study. Eur J Heart Fail 2006; 8: 697–705. doi: 10.1016/j.ejheart.2006.01.001
    [12]
    Chioncel O, Vinereanu D, Datcu M, et al. The Romanian Acute Heart Failure Syndromes (RO-AHFS) registry. Am Heart J 2011; 162: 142–153.e141. doi: 10.1016/j.ahj.2011.03.033
    [13]
    Spinar J, Parenica J, Vitovec J, et al. Baseline characteristics and hospital mortality in the Acute Heart Failure Database (AHEAD) Main registry. Crit Care 2011; 15: R291. doi: 10.1186/cc10584
    [14]
    Sato N, Kajimoto K, Keida T, et al. Clinical features and outcome in hospitalized heart failure in Japan (from the ATTEND Registry). Circ J 2013; 77: 944–951. doi: 10.1253/circj.CJ-13-0187
    [15]
    Atherton JJ, Hayward CS, Wan Ahmad WA, et al. Patient characteristics from a regional multicenter database of acute decompensated heart failure in Asia Pacific (ADHERE International-Asia Pacific). J Card Fail 2012; 18: 82–88. doi: 10.1016/j.cardfail.2011.09.003
    [16]
    Follath F, Yilmaz MB, Delgado JF, et al. Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM- HF). Intensive Care Med 2011; 37: 619–626. doi: 10.1007/s00134-010-2113-0
    [17]
    Steinberg BA, Zhao X, Heidenreich PA, et al. Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes. Circulation 2012; 126: 65–75. doi: 10.1161/CIRCULATIONAHA.111.080770
    [18]
    Zhang J, Zhang Yh.[China Heart Failure Registry Study-A Multicenter, Prospective Investigation for Preliminary Analysis on Etiology, Clinical Features and Treatment in Heart Failure Patients]. Chin Circ J 2015; 30: 413–416.[Article in Chinese]. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgxhzz201505002
    [19]
    https://data.worldbank.org.cn/ (accessed July 24, 2005).
    [20]
    [21]
    Ambrosy AP, Fonarow GC, Butler J, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 2014; 63: 1123–1133. doi: 10.1016/j.jacc.2013.11.053
    [22]
    Lourenco AP, Leite-Moreira AF, Balligand JL, et al. An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. Eur J Heart Fail 2018; 20: 216–227. doi: 10.1002/ejhf.1059
    [23]
    Komajda M, Hanon O, Hochadel M, et al. Contemporary management of octogenarians hospitalized for heart failure in Europe: Euro Heart Failure Survey Ⅱ. Eur Heart J 2009; 30: 478–486. http://www.ncbi.nlm.nih.gov/pubmed/19106198
    [24]
    Gattis WA, O'Connor CM, Gallup DS, et al. Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial. J Am Coll Cardiol 2004; 43: 1534–1541. doi: 10.1016/j.jacc.2003.12.040
    [25]
    Bavishi C, Ather S, Bambhroliya A, et al. Prognostic significance of hyponatremia among ambulatory patients with heart failure and preserved and reduced ejection fractions. Am J Cardiol 2014; 113: 1834–1838. doi: 10.1016/j.amjcard.2014.03.017
    [26]
    Gheorghiade M, Abraham WT, Albert NM, et al. Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. Eur Heart J 2007; 28: 980–988. doi: 10.1093/eurheartj/ehl542
    [27]
    Gheorghiade M, Rossi JS, Cotts W, et al. Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE Trial. Arch Intern Med 2007; 167: 1998–2005. doi: 10.1001/archinte.167.18.1998
    [28]
    Klein L, O'Connor CM, Leimberger JD, et al. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. Circulation 2005; 111: 2454–2460. doi: 10.1161/01.CIR.0000165065.82609.3D
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(5)  / Tables(1)

    Article Metrics

    Article views (265) PDF downloads(28) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return